Prevention of Prosthetic Joint Infection: From Traditional Approaches towards Quality Improvement and Data Mining

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F20%3AN0000124" target="_blank" >RIV/00098892:_____/20:N0000124 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15110/20:73601215

Výsledek na webu

<a href="https://www.mdpi.com/2077-0383/9/7/2190/htm" target="_blank" >https://www.mdpi.com/2077-0383/9/7/2190/htm</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/jcm9072190" target="_blank" >10.3390/jcm9072190</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Prevention of Prosthetic Joint Infection: From Traditional Approaches towards Quality Improvement and Data Mining

Popis výsledku v původním jazyce

A projected increased use of total joint arthroplasties will naturally result in a related increase in the number of prosthetic joint infections (PJIs). Suppression of the local peri-implant immune response counters efforts to eradicate bacteria, allowing the formation of biofilms and compromising preventive measures taken in the operating room. For these reasons, the prevention of PJI should focus concurrently on the following targets: (i) identifying at-risk patients; (ii) reducing "bacterial load" perioperatively; (iii) creating an antibacterial/antibiofilm environment at the site of surgery; and (iv) stimulating the local immune response. Despite considerable recent progress made in experimental and clinical research, a large discrepancy persists between proposed and clinically implemented preventative strategies. The ultimate anti-infective strategy lies in an optimal combination of all preventative approaches into a single "clinical pack", applied rigorously in all settings involving prosthetic joint implantation. In addition, "anti-infective" implants might be a choice in patients who have an increased risk for PJI. However, further progress in the prevention of PJI is not imaginable without a close commitment to using quality improvement tools in combination with continual data mining, reflecting the efficacy of the preventative strategy in a particular clinical setting.

Název v anglickém jazyce

Prevention of Prosthetic Joint Infection: From Traditional Approaches towards Quality Improvement and Data Mining

Popis výsledku anglicky

A projected increased use of total joint arthroplasties will naturally result in a related increase in the number of prosthetic joint infections (PJIs). Suppression of the local peri-implant immune response counters efforts to eradicate bacteria, allowing the formation of biofilms and compromising preventive measures taken in the operating room. For these reasons, the prevention of PJI should focus concurrently on the following targets: (i) identifying at-risk patients; (ii) reducing "bacterial load" perioperatively; (iii) creating an antibacterial/antibiofilm environment at the site of surgery; and (iv) stimulating the local immune response. Despite considerable recent progress made in experimental and clinical research, a large discrepancy persists between proposed and clinically implemented preventative strategies. The ultimate anti-infective strategy lies in an optimal combination of all preventative approaches into a single "clinical pack", applied rigorously in all settings involving prosthetic joint implantation. In addition, "anti-infective" implants might be a choice in patients who have an increased risk for PJI. However, further progress in the prevention of PJI is not imaginable without a close commitment to using quality improvement tools in combination with continual data mining, reflecting the efficacy of the preventative strategy in a particular clinical setting.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30211 - Orthopaedics

Projekt

<a href="/cs/project/NV17-29680A" target="_blank" >NV17-29680A: Použití lipofosfonoxinů k prevenci a léčbě muskuloskeletárních infekcí: potenciální role nových antibakteriálních látek</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Clinical Medicine

ISSN

2077-0383

e-ISSN

2077-0383

Svazek periodika

9

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

26

Strana od-do

2190

Kód UT WoS článku

000554244200001

EID výsledku v databázi Scopus

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