Current trends in the diagnosis of pancreatic cancer

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F22%3A10157477" target="_blank" >RIV/00098892:_____/22:10157477 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/65269705:_____/22:00076383 RIV/00209805:_____/22:00079067 RIV/00216224:14110/22:00126942 RIV/61989592:15110/22:73614785

Výsledek na webu

<a href="https://casopisvnitrnilekarstvi.cz/artkey/vnl-202206-0002_current-trends-in-the-diagnosis-of-pancreatic-cancer.php" target="_blank" >https://casopisvnitrnilekarstvi.cz/artkey/vnl-202206-0002_current-trends-in-the-diagnosis-of-pancreatic-cancer.php</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.36290/vnl.2022.076" target="_blank" >10.36290/vnl.2022.076</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Current trends in the diagnosis of pancreatic cancer

Popis výsledku v původním jazyce

Pancreatic ductal adenocarcinoma (PDAC) is a dreaded malignancy with a dismal 5-year survival rate despite maximal efforts on optimizing treatment strategies. Currently, early detection is considered to be the most effective way to improve survival as radical resection is the only potential cure. PDAC is often divided into four categories based on the extent of disease: resectable, borderline resectable, locally advanced, and metastatic. Unfortunately, the majority of patients are diagnosed with locally advanced or metastatic disease, which renders them ineligible for curative resection. This is mainly due to the lack of or vague symptoms while the disease is still localized, although appropriate utilization and prompt availability of adequate diagnostic tools is also critical given the aggressive nature of the disease. A cost-effective biomarker with high specificity and sensitivity allowing early detection of PDAC without the need for advanced or invasive methods is still not available. This leaves the diagnosis dependent on radiodiagnostic methods or endoscopic ultrasound. Here we summarize the latest epidemiological data, risk factors, clinical manifestation, and current diagnostic trends and implications of PDAC focusing on serum biomarkers and imaging modalities. Additionally, up-to-date management and therapeutic algorithms are outlined.

Název v anglickém jazyce

Current trends in the diagnosis of pancreatic cancer

Popis výsledku anglicky

Pancreatic ductal adenocarcinoma (PDAC) is a dreaded malignancy with a dismal 5-year survival rate despite maximal efforts on optimizing treatment strategies. Currently, early detection is considered to be the most effective way to improve survival as radical resection is the only potential cure. PDAC is often divided into four categories based on the extent of disease: resectable, borderline resectable, locally advanced, and metastatic. Unfortunately, the majority of patients are diagnosed with locally advanced or metastatic disease, which renders them ineligible for curative resection. This is mainly due to the lack of or vague symptoms while the disease is still localized, although appropriate utilization and prompt availability of adequate diagnostic tools is also critical given the aggressive nature of the disease. A cost-effective biomarker with high specificity and sensitivity allowing early detection of PDAC without the need for advanced or invasive methods is still not available. This leaves the diagnosis dependent on radiodiagnostic methods or endoscopic ultrasound. Here we summarize the latest epidemiological data, risk factors, clinical manifestation, and current diagnostic trends and implications of PDAC focusing on serum biomarkers and imaging modalities. Additionally, up-to-date management and therapeutic algorithms are outlined.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

30219 - Gastroenterology and hepatology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Vnitřní lékařství

ISSN

0042-773X

e-ISSN

1801-7592

Svazek periodika

68

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

8

Strana od-do

363-370

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85139753435