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Ocular hypertension in patients with active thyroid-associated orbitopathy: a predictor of disease severity, particularly of extraocular muscle enlargement

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F22%3A10157560" target="_blank" >RIV/00098892:_____/22:10157560 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/61989592:15110/22:73615729

  • Výsledek na webu

    <a href="https://link.springer.com/article/10.1007/s00417-022-05760-0" target="_blank" >https://link.springer.com/article/10.1007/s00417-022-05760-0</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s00417-022-05760-0" target="_blank" >10.1007/s00417-022-05760-0</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Ocular hypertension in patients with active thyroid-associated orbitopathy: a predictor of disease severity, particularly of extraocular muscle enlargement

  • Popis výsledku v původním jazyce

    The purpose was to ascertain if any relation exists between the elevated intraocular pressure (IOP) in patients with thyroid-associated orbitopathy (TAO) in active stage and the severity of extraocular muscle involvement and the extent of exophthalmos. Methods: A total of 96 eyes and orbits of 48 adult patients with active TAO were investigated. All patients underwent magnetic resonance imaging of the orbit and measurement of all extraocular recti muscles (EOM). The obtained data was divided into two groups according to the IOP value: normal IOP ≤ 21 mmHg; n=47 and elevated IOP with IOP > 21 mmHg; n=49, and analyszed. Results: A signifcant diference was found in the short diameter of medial rectus and inferior rectus muscles and in the sum of short parameters of all EOM. All these parameters were signifcantly higher in the elevated IOP group. Motility restriction in at least one gaze direction was also signifcantly more frequent (p < 0.0001) in the elevated IOP group. A positive moderate correlation was found between IOP and the sum of short parameters of EOM (r=0.496). No correlation was found between the IOP and exophthalmos values (r=0.267). During the follow-up, the frequency of strabismus surgery and orbital decompression was signifcantly higher in the elevated IOP group (p=0.003; p=0.002). Conclusion: Elevated IOP in the active TAO stage particularly correlates with extraocular muscle involvement. These patients are also more likely to require orbital decompression and strabismus surgery.

  • Název v anglickém jazyce

    Ocular hypertension in patients with active thyroid-associated orbitopathy: a predictor of disease severity, particularly of extraocular muscle enlargement

  • Popis výsledku anglicky

    The purpose was to ascertain if any relation exists between the elevated intraocular pressure (IOP) in patients with thyroid-associated orbitopathy (TAO) in active stage and the severity of extraocular muscle involvement and the extent of exophthalmos. Methods: A total of 96 eyes and orbits of 48 adult patients with active TAO were investigated. All patients underwent magnetic resonance imaging of the orbit and measurement of all extraocular recti muscles (EOM). The obtained data was divided into two groups according to the IOP value: normal IOP ≤ 21 mmHg; n=47 and elevated IOP with IOP > 21 mmHg; n=49, and analyszed. Results: A signifcant diference was found in the short diameter of medial rectus and inferior rectus muscles and in the sum of short parameters of all EOM. All these parameters were signifcantly higher in the elevated IOP group. Motility restriction in at least one gaze direction was also signifcantly more frequent (p < 0.0001) in the elevated IOP group. A positive moderate correlation was found between IOP and the sum of short parameters of EOM (r=0.496). No correlation was found between the IOP and exophthalmos values (r=0.267). During the follow-up, the frequency of strabismus surgery and orbital decompression was signifcantly higher in the elevated IOP group (p=0.003; p=0.002). Conclusion: Elevated IOP in the active TAO stage particularly correlates with extraocular muscle involvement. These patients are also more likely to require orbital decompression and strabismus surgery.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    30207 - Ophthalmology

Návaznosti výsledku

  • Projekt

    <a href="/cs/project/NU21J-01-00017" target="_blank" >NU21J-01-00017: Včasná detekce rozvoje endokrinní orbitopatie u pacientů s dysfunkcí štítné žlázy a metody hodnocení její aktivity a závažnosti</a><br>

  • Návaznosti

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Ostatní

  • Rok uplatnění

    2022

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Graefe's archive for clinical and experimental ophthalmology.

  • ISSN

    0721-832X

  • e-ISSN

    1435-702X

  • Svazek periodika

    260

  • Číslo periodika v rámci svazku

    12

  • Stát vydavatele periodika

    US - Spojené státy americké

  • Počet stran výsledku

    8

  • Strana od-do

    3977-3984

  • Kód UT WoS článku

    000825175900001

  • EID výsledku v databázi Scopus

    2-s2.0-85134317857