Ocular hypertension in patients with active thyroid-associated orbitopathy: a predictor of disease severity, particularly of extraocular muscle enlargement
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F22%3A10157560" target="_blank" >RIV/00098892:_____/22:10157560 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/61989592:15110/22:73615729
Výsledek na webu
<a href="https://link.springer.com/article/10.1007/s00417-022-05760-0" target="_blank" >https://link.springer.com/article/10.1007/s00417-022-05760-0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00417-022-05760-0" target="_blank" >10.1007/s00417-022-05760-0</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Ocular hypertension in patients with active thyroid-associated orbitopathy: a predictor of disease severity, particularly of extraocular muscle enlargement
Popis výsledku v původním jazyce
The purpose was to ascertain if any relation exists between the elevated intraocular pressure (IOP) in patients with thyroid-associated orbitopathy (TAO) in active stage and the severity of extraocular muscle involvement and the extent of exophthalmos. Methods: A total of 96 eyes and orbits of 48 adult patients with active TAO were investigated. All patients underwent magnetic resonance imaging of the orbit and measurement of all extraocular recti muscles (EOM). The obtained data was divided into two groups according to the IOP value: normal IOP ≤ 21 mmHg; n=47 and elevated IOP with IOP > 21 mmHg; n=49, and analyszed. Results: A signifcant diference was found in the short diameter of medial rectus and inferior rectus muscles and in the sum of short parameters of all EOM. All these parameters were signifcantly higher in the elevated IOP group. Motility restriction in at least one gaze direction was also signifcantly more frequent (p < 0.0001) in the elevated IOP group. A positive moderate correlation was found between IOP and the sum of short parameters of EOM (r=0.496). No correlation was found between the IOP and exophthalmos values (r=0.267). During the follow-up, the frequency of strabismus surgery and orbital decompression was signifcantly higher in the elevated IOP group (p=0.003; p=0.002). Conclusion: Elevated IOP in the active TAO stage particularly correlates with extraocular muscle involvement. These patients are also more likely to require orbital decompression and strabismus surgery.
Název v anglickém jazyce
Ocular hypertension in patients with active thyroid-associated orbitopathy: a predictor of disease severity, particularly of extraocular muscle enlargement
Popis výsledku anglicky
The purpose was to ascertain if any relation exists between the elevated intraocular pressure (IOP) in patients with thyroid-associated orbitopathy (TAO) in active stage and the severity of extraocular muscle involvement and the extent of exophthalmos. Methods: A total of 96 eyes and orbits of 48 adult patients with active TAO were investigated. All patients underwent magnetic resonance imaging of the orbit and measurement of all extraocular recti muscles (EOM). The obtained data was divided into two groups according to the IOP value: normal IOP ≤ 21 mmHg; n=47 and elevated IOP with IOP > 21 mmHg; n=49, and analyszed. Results: A signifcant diference was found in the short diameter of medial rectus and inferior rectus muscles and in the sum of short parameters of all EOM. All these parameters were signifcantly higher in the elevated IOP group. Motility restriction in at least one gaze direction was also signifcantly more frequent (p < 0.0001) in the elevated IOP group. A positive moderate correlation was found between IOP and the sum of short parameters of EOM (r=0.496). No correlation was found between the IOP and exophthalmos values (r=0.267). During the follow-up, the frequency of strabismus surgery and orbital decompression was signifcantly higher in the elevated IOP group (p=0.003; p=0.002). Conclusion: Elevated IOP in the active TAO stage particularly correlates with extraocular muscle involvement. These patients are also more likely to require orbital decompression and strabismus surgery.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30207 - Ophthalmology
Návaznosti výsledku
Projekt
<a href="/cs/project/NU21J-01-00017" target="_blank" >NU21J-01-00017: Včasná detekce rozvoje endokrinní orbitopatie u pacientů s dysfunkcí štítné žlázy a metody hodnocení její aktivity a závažnosti</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2022
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Graefe's archive for clinical and experimental ophthalmology.
ISSN
0721-832X
e-ISSN
1435-702X
Svazek periodika
260
Číslo periodika v rámci svazku
12
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
8
Strana od-do
3977-3984
Kód UT WoS článku
000825175900001
EID výsledku v databázi Scopus
2-s2.0-85134317857