Which bacterial toxins are worthy of validation as markers in colorectal cancer screening? A critical review

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F22%3A10157732" target="_blank" >RIV/00098892:_____/22:10157732 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15110/22:73609395

Výsledek na webu

<a href="https://biomed.papers.upol.cz/artkey/bio-202201-0001_which-bacterial-toxins-are-worthy-of-validation-as-markers-in-colorectal-cancer-screening-a-critical-review.php" target="_blank" >https://biomed.papers.upol.cz/artkey/bio-202201-0001_which-bacterial-toxins-are-worthy-of-validation-as-markers-in-colorectal-cancer-screening-a-critical-review.php</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2021.054" target="_blank" >10.5507/bp.2021.054</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Which bacterial toxins are worthy of validation as markers in colorectal cancer screening? A critical review

Popis výsledku v původním jazyce

Appropriate screening of early asymptomatic cases can reduce the disease burden and mortality rate of sporadic colorectal cancer (CRC) significantly. Currently, fecal occult blood testing (FOBT) is able to detect up to 80% of asymptomatic cases in the population aged 50+. Therefore, there is still a demand for new screening tests that would complement FOBT, mainly by detecting at least a part of the FOBT-negative CRC and adenoma cases, or possibly by identifying person at increased risk of sporadic CRC in order to offer them tailored follow-up. Among the potential markers studied, our knowledge has advanced at most in toxigenic gram-negative bacteria. In this review, we assess their potential critically and recommend those best suited for prospective evaluation of their true ability to increase the sensitivity of FOBT when combined during general population screening. In our opinion, colibactin and Bacteroides fragilis toxin are the best candidates, possibly complemented by the cytotoxic necrotizing factor (CNF).

Název v anglickém jazyce

Which bacterial toxins are worthy of validation as markers in colorectal cancer screening? A critical review

Popis výsledku anglicky

Appropriate screening of early asymptomatic cases can reduce the disease burden and mortality rate of sporadic colorectal cancer (CRC) significantly. Currently, fecal occult blood testing (FOBT) is able to detect up to 80% of asymptomatic cases in the population aged 50+. Therefore, there is still a demand for new screening tests that would complement FOBT, mainly by detecting at least a part of the FOBT-negative CRC and adenoma cases, or possibly by identifying person at increased risk of sporadic CRC in order to offer them tailored follow-up. Among the potential markers studied, our knowledge has advanced at most in toxigenic gram-negative bacteria. In this review, we assess their potential critically and recommend those best suited for prospective evaluation of their true ability to increase the sensitivity of FOBT when combined during general population screening. In our opinion, colibactin and Bacteroides fragilis toxin are the best candidates, possibly complemented by the cytotoxic necrotizing factor (CNF).

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10606 - Microbiology

Projekt

<a href="/cs/project/NV19-03-00069" target="_blank" >NV19-03-00069: Korelace molekulárních biomarkerů potenciálně důležitých pro imunoterapii s kvalitou střevního mikrobiomu u pacientů s NSCLC</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedical Papers-Olomouc

ISSN

1213-8118

e-ISSN

1804-7521

Svazek periodika

166

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

11

Strana od-do

1-11

Kód UT WoS článku

000731340000001

EID výsledku v databázi Scopus

2-s2.0-85126490980