Medical Termination of Pregnancy (MToP) in the 1st trimester – the role of human chorionic gonadotropin and ultrasound in pregnancy diagnosis and MToP follow-up

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F23%3A10158258" target="_blank" >RIV/00098892:_____/23:10158258 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15110/23:73622106

Výsledek na webu

<a href="https://redakce.carecomm.cz/cgyn/article/view/2108" target="_blank" >https://redakce.carecomm.cz/cgyn/article/view/2108</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.48095/cccg2023420" target="_blank" >10.48095/cccg2023420</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Medical Termination of Pregnancy (MToP) in the 1st trimester – the role of human chorionic gonadotropin and ultrasound in pregnancy diagnosis and MToP follow-up

Popis výsledku v původním jazyce

Objective: In the Czech Republic, it is possible, to carry out Medical Termination of Pregnancy (MTOP) in the 1st trimester up until the 49th day of secondary amenorrhea. The aim of the study is to analyse the significance of serum/urine human chorionic gonadotropin (hCG) assessment and ultrasound (US) examination in pregnancy diagnosis and MTOP follow-up. Methods: In 2017–2018, MTOP was carried out in a total of 109 women by administering a combination of mifepristone (600 mg orally) and misoprostol (400 mcg orally). Serum/urine (LSUP-low sensitivity urine pregnancy test) hCG assessment and US examination were performed at pregnancy diagnosis and MTOP follow-up. Results: At pregnancy diagnosis, there was a positive and medium strong correlation between serum hCG and size of the gestational sac – GS (R = 0.711; P &lt; 0.0001) and crown-rump length of the embryo – CRL (R = 0.605; P &lt; 0.0001). Gestational age was 42–49 days (average 45.6, median 45 days), the women were 16–44 years of age (average 29.4, median 29 years). In MTOP follow-up, serum hCG level was &gt; 1,000 IU/L in 13.8% of women (15/109) and a positive LSUP test in 17.4% (20/109). US examination diagnosed ongoing pregnancy in five women and missed abortion in one woman (serum hCG was always &gt; 1,000 IU/L and LSUP test was always positive). In 5.5% of women (6/109), a subsequent surgical intervention was carried out including those with ongoing pregnancy (N = 5); missed abortion (N = 1) was treated by additional misoprostol, where surgical intervention was not necessary. Conclusion: At pregnancy diagnosis, there is a positive and medium strong correlation between serum hCG and CRL. In MTOP follow-up, a negative LSUP test enables reliable exclusion of ongoing pregnancy and missed abortion. In case of a positive LSUP test, US examination should be performed; however, surgical intervention should not be indicated solely on the basis of uterine cavity dilatation.

Název v anglickém jazyce

Medical Termination of Pregnancy (MToP) in the 1st trimester – the role of human chorionic gonadotropin and ultrasound in pregnancy diagnosis and MToP follow-up

Popis výsledku anglicky

Objective: In the Czech Republic, it is possible, to carry out Medical Termination of Pregnancy (MTOP) in the 1st trimester up until the 49th day of secondary amenorrhea. The aim of the study is to analyse the significance of serum/urine human chorionic gonadotropin (hCG) assessment and ultrasound (US) examination in pregnancy diagnosis and MTOP follow-up. Methods: In 2017–2018, MTOP was carried out in a total of 109 women by administering a combination of mifepristone (600 mg orally) and misoprostol (400 mcg orally). Serum/urine (LSUP-low sensitivity urine pregnancy test) hCG assessment and US examination were performed at pregnancy diagnosis and MTOP follow-up. Results: At pregnancy diagnosis, there was a positive and medium strong correlation between serum hCG and size of the gestational sac – GS (R = 0.711; P &lt; 0.0001) and crown-rump length of the embryo – CRL (R = 0.605; P &lt; 0.0001). Gestational age was 42–49 days (average 45.6, median 45 days), the women were 16–44 years of age (average 29.4, median 29 years). In MTOP follow-up, serum hCG level was &gt; 1,000 IU/L in 13.8% of women (15/109) and a positive LSUP test in 17.4% (20/109). US examination diagnosed ongoing pregnancy in five women and missed abortion in one woman (serum hCG was always &gt; 1,000 IU/L and LSUP test was always positive). In 5.5% of women (6/109), a subsequent surgical intervention was carried out including those with ongoing pregnancy (N = 5); missed abortion (N = 1) was treated by additional misoprostol, where surgical intervention was not necessary. Conclusion: At pregnancy diagnosis, there is a positive and medium strong correlation between serum hCG and CRL. In MTOP follow-up, a negative LSUP test enables reliable exclusion of ongoing pregnancy and missed abortion. In case of a positive LSUP test, US examination should be performed; however, surgical intervention should not be indicated solely on the basis of uterine cavity dilatation.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30214 - Obstetrics and gynaecology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Česká gynekologie

ISSN

1210-7832

e-ISSN

1805-4455

Svazek periodika

88

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

8

Strana od-do

420-427

Kód UT WoS článku

001179280900001

EID výsledku v databázi Scopus

2-s2.0-85181764864