Immunohistochemical evaluation of tissues following bone implant extraction from upper and lower limb

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F23%3A10158375" target="_blank" >RIV/00098892:_____/23:10158375 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00843989:_____/23:E0110380 RIV/61988987:17110/23:A2402L1E RIV/61989100:27350/23:10252103 RIV/61989100:27360/23:10252103 RIV/61989100:27640/23:10252103

Výsledek na webu

<a href="https://www.hh.um.es/Abstracts/Vol_38/38_10/38_10_1119.htm" target="_blank" >https://www.hh.um.es/Abstracts/Vol_38/38_10/38_10_1119.htm</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14670/HH-18-606" target="_blank" >10.14670/HH-18-606</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Immunohistochemical evaluation of tissues following bone implant extraction from upper and lower limb

Popis výsledku v původním jazyce

Fractured bones can regenerate and restore their biological and mechanical properties to the state prior to the damage. In some cases, however, the treatment of fractures requires the use of supportive implants. For bone healing, three processes are essential: the inflammatory phase, the repair phase and the remodelling phase. A proper course of the first - inflammatory stage is important to ensure a successful fracture healing process. In our study, we evaluated tissue samples immunohistochemically from the area surrounding the fractures of upper and lower limbs (bone tissue, soft tissue, and the implant-adhering tissue) for markers: CD11b, CD15, CD34, CD44, CD68, Cathepsin K, and TRAcP that are linked to the aforementioned phases. In soft tissue, higher expressions of CD68, CD34, CD15 and CD11b markers were observed than in other locations. TRAcP and Cathepsin K markers were more expressed in the bone tissue, while pigmentation, necrosis and calcification were more observed in the implant-adhering tissue. Since even the implant materials commonly perceived as inert elicit the observed inflammatory responses, new surface treatments and materials need to be developed.

Název v anglickém jazyce

Immunohistochemical evaluation of tissues following bone implant extraction from upper and lower limb

Popis výsledku anglicky

Fractured bones can regenerate and restore their biological and mechanical properties to the state prior to the damage. In some cases, however, the treatment of fractures requires the use of supportive implants. For bone healing, three processes are essential: the inflammatory phase, the repair phase and the remodelling phase. A proper course of the first - inflammatory stage is important to ensure a successful fracture healing process. In our study, we evaluated tissue samples immunohistochemically from the area surrounding the fractures of upper and lower limbs (bone tissue, soft tissue, and the implant-adhering tissue) for markers: CD11b, CD15, CD34, CD44, CD68, Cathepsin K, and TRAcP that are linked to the aforementioned phases. In soft tissue, higher expressions of CD68, CD34, CD15 and CD11b markers were observed than in other locations. TRAcP and Cathepsin K markers were more expressed in the bone tissue, while pigmentation, necrosis and calcification were more observed in the implant-adhering tissue. Since even the implant materials commonly perceived as inert elicit the observed inflammatory responses, new surface treatments and materials need to be developed.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30109 - Pathology

Projekt

<a href="/cs/project/EF17_049%2F0008441" target="_blank" >EF17_049/0008441: Inovativní léčebné metody pohybového aparátu v úrazové chirurgii</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Histology and Histopathology

ISSN

0213-3911

e-ISSN

1699-5848

Svazek periodika

38

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

ES - Španělské království

Počet stran výsledku

9

Strana od-do

1119-1127

Kód UT WoS článku

001134740600004

EID výsledku v databázi Scopus

2-s2.0-85173584527