Exploring the protective effects of soluble cytokinin salt p-topolin mesylate on skin through antioxidant activity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F25%3A10159548" target="_blank" >RIV/00098892:_____/25:10159548 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S2211715625008549?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2211715625008549?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.rechem.2025.102870" target="_blank" >10.1016/j.rechem.2025.102870</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Exploring the protective effects of soluble cytokinin salt p-topolin mesylate on skin through antioxidant activity

Popis výsledku v původním jazyce

Cytokinins, known as the compounds of natural origin, play a significant regulatory role in the senescence in plants. Several of them, such as 6-furfurylaminopurine (kinetin), also showed beneficial effects on human skin cells. We focused on structurally similar cytokinin 6-(4-hydroxybenzylamino)purine, p-topolin (pT), and its water-soluble mesylate salt (pTM). Newly prepared salt is 60 000 times more soluble in water than pT. Both compounds are UVA photostable, non-toxic and non-phototoxic. We also explored UVA protective effect on human fibroblasts (NHDF), keratinocytes (HaCaT) and porcine ear skin. Since the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway regulates various genes in regulation of oxidative stress, we focused on effects of pT and pTM in this manner. Both compounds increased translocation of Nrf2 transcription factor to the nucleus in NHDF and stimulated the accumulation of Bach1, a Nrf2 transcription regulator in HaCaT. Studied compounds also significantly reduced UVA-induced UPE (ultra-weak photon emission) related to reactive oxygen species (ROS) formation in skin cells and porcine ear skin ex vivo, in which pTM was found to have higher protective effect compared to pT.

Název v anglickém jazyce

Exploring the protective effects of soluble cytokinin salt p-topolin mesylate on skin through antioxidant activity

Popis výsledku anglicky

Cytokinins, known as the compounds of natural origin, play a significant regulatory role in the senescence in plants. Several of them, such as 6-furfurylaminopurine (kinetin), also showed beneficial effects on human skin cells. We focused on structurally similar cytokinin 6-(4-hydroxybenzylamino)purine, p-topolin (pT), and its water-soluble mesylate salt (pTM). Newly prepared salt is 60 000 times more soluble in water than pT. Both compounds are UVA photostable, non-toxic and non-phototoxic. We also explored UVA protective effect on human fibroblasts (NHDF), keratinocytes (HaCaT) and porcine ear skin. Since the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway regulates various genes in regulation of oxidative stress, we focused on effects of pT and pTM in this manner. Both compounds increased translocation of Nrf2 transcription factor to the nucleus in NHDF and stimulated the accumulation of Bach1, a Nrf2 transcription regulator in HaCaT. Studied compounds also significantly reduced UVA-induced UPE (ultra-weak photon emission) related to reactive oxygen species (ROS) formation in skin cells and porcine ear skin ex vivo, in which pTM was found to have higher protective effect compared to pT.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30107 - Medicinal chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Results in Chemistry

ISSN

—

e-ISSN

2211-7156

Svazek periodika

18

Číslo periodika v rámci svazku

November

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

14

Strana od-do

102870

Kód UT WoS článku

001617864700002

EID výsledku v databázi Scopus

2-s2.0-105021242811