Does Sex Influence the Response to Intravenous Thrombolysis in Ischemic Stroke? Answers From Safe Implementation of Treatments in Stroke-International Stroke Thrombolysis Register

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F13%3A00060572" target="_blank" >RIV/00159816:_____/13:00060572 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1161/STROKEAHA.113.002908" target="_blank" >http://dx.doi.org/10.1161/STROKEAHA.113.002908</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1161/STROKEAHA.113.002908" target="_blank" >10.1161/STROKEAHA.113.002908</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Does Sex Influence the Response to Intravenous Thrombolysis in Ischemic Stroke? Answers From Safe Implementation of Treatments in Stroke-International Stroke Thrombolysis Register

Popis výsledku v původním jazyce

Background and Purpose Women are more likely to have a worse outcome after an acute stroke than men. Some studies have suggested that women also benefit less from intravenous thrombolysis after an acute ischemic stroke, but others found no sex differences in safety and efficacy. We aimed to evaluate differences in 3-month outcome between sexes in intravenous tissue-type plasminogen activator-treated patients registered in the Safe Implementation of Treatments in Stroke-International Stroke ThrombolysisRegister. Methods A total of 45 079 patients treated with intravenous alteplase were recorded from 2002 to 2011. Main outcome measures were symptomatic intracerebral hemorrhage, functional independence (modified Rankin Scale score, 0-2), and mortality at3 months. Results Among 25 777 (57.2%) men and 19 302 (42.8%) women, we found no difference in the rate of symptomatic intracerebral hemorrhage (P=0.13), a significantly higher likelihood of functional independence at 3 months in men (P<

Název v anglickém jazyce

Does Sex Influence the Response to Intravenous Thrombolysis in Ischemic Stroke? Answers From Safe Implementation of Treatments in Stroke-International Stroke Thrombolysis Register

Popis výsledku anglicky

Background and Purpose Women are more likely to have a worse outcome after an acute stroke than men. Some studies have suggested that women also benefit less from intravenous thrombolysis after an acute ischemic stroke, but others found no sex differences in safety and efficacy. We aimed to evaluate differences in 3-month outcome between sexes in intravenous tissue-type plasminogen activator-treated patients registered in the Safe Implementation of Treatments in Stroke-International Stroke ThrombolysisRegister. Methods A total of 45 079 patients treated with intravenous alteplase were recorded from 2002 to 2011. Main outcome measures were symptomatic intracerebral hemorrhage, functional independence (modified Rankin Scale score, 0-2), and mortality at3 months. Results Among 25 777 (57.2%) men and 19 302 (42.8%) women, we found no difference in the rate of symptomatic intracerebral hemorrhage (P=0.13), a significantly higher likelihood of functional independence at 3 months in men (P<

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: Fakultní nemocnice u sv. Anny v Brně - Mezinárodní centrum klinického výzkumu (FNUSA - ICRC)</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Stroke

ISSN

0039-2499

e-ISSN

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Svazek periodika

44

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

3401-3406

Kód UT WoS článku

000327386300311

EID výsledku v databázi Scopus

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