Results of Intravenous Thrombolysis Within 4.5 to 6 Hours and Updated Results Within 3 to 4.5 Hours of Onset of Acute Ischemic Stroke Recorded in the Safe Implementation of Treatment in Stroke International Stroke Thrombolysis Register (SITS-ISTR) An Observational Study
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F13%3A00060788" target="_blank" >RIV/00159816:_____/13:00060788 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1001/jamaneurol.2013.406" target="_blank" >http://dx.doi.org/10.1001/jamaneurol.2013.406</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1001/jamaneurol.2013.406" target="_blank" >10.1001/jamaneurol.2013.406</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Results of Intravenous Thrombolysis Within 4.5 to 6 Hours and Updated Results Within 3 to 4.5 Hours of Onset of Acute Ischemic Stroke Recorded in the Safe Implementation of Treatment in Stroke International Stroke Thrombolysis Register (SITS-ISTR) An Observational Study
Popis výsledku v původním jazyce
IMPORTANCE Pooled analysis of randomized controlled trials of intravenous thrombolysis shows no statistically significant benefit beyond 4.5 hours, with the possible advantage perhaps offset by risk. OBJECTIVE To compare the outcomes of patients who weretreated within 4.5 to 6 hours or within 3 to 4.5 hours of the onset of an ischemic stroke with the outcomes of patients who were treated within 3 hours in the SITS-ISTR. DESIGN An observational study based on SITS-ISTR data during the period from 2002 to 2011. SETTING Acute and emergency care. PARTICIPANTS Of 29 618 patients with acute ischemic stroke, 283 (1.0%) were treated within 4.5 to 6 hours of onset, 4056 (13.7%) were within 3 to 4.5 hours of onset, and 25 279 (85.4%) were treated within 3 hoursof onset, in compliance with other European Union approval criteria. EXPOSURE Intravenous thrombolysis with alteplase. MAIN OUTCOMES AND MEASURES Functional independence (modified Rankin Scale score of 0-2) and mortality at 3 months and
Název v anglickém jazyce
Results of Intravenous Thrombolysis Within 4.5 to 6 Hours and Updated Results Within 3 to 4.5 Hours of Onset of Acute Ischemic Stroke Recorded in the Safe Implementation of Treatment in Stroke International Stroke Thrombolysis Register (SITS-ISTR) An Observational Study
Popis výsledku anglicky
IMPORTANCE Pooled analysis of randomized controlled trials of intravenous thrombolysis shows no statistically significant benefit beyond 4.5 hours, with the possible advantage perhaps offset by risk. OBJECTIVE To compare the outcomes of patients who weretreated within 4.5 to 6 hours or within 3 to 4.5 hours of the onset of an ischemic stroke with the outcomes of patients who were treated within 3 hours in the SITS-ISTR. DESIGN An observational study based on SITS-ISTR data during the period from 2002 to 2011. SETTING Acute and emergency care. PARTICIPANTS Of 29 618 patients with acute ischemic stroke, 283 (1.0%) were treated within 4.5 to 6 hours of onset, 4056 (13.7%) were within 3 to 4.5 hours of onset, and 25 279 (85.4%) were treated within 3 hoursof onset, in compliance with other European Union approval criteria. EXPOSURE Intravenous thrombolysis with alteplase. MAIN OUTCOMES AND MEASURES Functional independence (modified Rankin Scale score of 0-2) and mortality at 3 months and
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FH - Neurologie, neurochirurgie, neurovědy
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: Fakultní nemocnice u sv. Anny v Brně - Mezinárodní centrum klinického výzkumu (FNUSA - ICRC)</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
JAMA neurology
ISSN
2168-6149
e-ISSN
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Svazek periodika
70
Číslo periodika v rámci svazku
7
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
8
Strana od-do
837-844
Kód UT WoS článku
000323563000005
EID výsledku v databázi Scopus
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