From Na+/K+-ATPase and Cardiac Glycosides to Cytotoxicity and Cancer Treatment

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F13%3A00063519" target="_blank" >RIV/00159816:_____/13:00063519 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62156489:43210/13:00212729 RIV/00216305:26220/13:PU105353

Výsledek na webu

<a href="http://dx.doi.org/10.2174/18715206113139990304" target="_blank" >http://dx.doi.org/10.2174/18715206113139990304</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/18715206113139990304" target="_blank" >10.2174/18715206113139990304</a>

Jazyk výsledku

angličtina

Název v původním jazyce

From Na+/K+-ATPase and Cardiac Glycosides to Cytotoxicity and Cancer Treatment

Popis výsledku v původním jazyce

The cardiac glycosides are a group of compounds isolated from plants and some animals. They have been used in therapy for heart failure for many years. The cytotoxic effect of many cardiac glycosides has been demonstrated, but the mechanism of action isvery complicated and complex, and Na+/K+-ATPase surely plays a crucial role in it. On the other hand, Na+/K+-ATPase is regulated by many endogenous factors, such as hormones or FXYD proteins, whose role in regulating the cell cycle has been studied intensively. This review focuses on the role of Na+/K+-ATPase in regulating the cell growth, the cell cycle and the cell proliferation and on the involvement of cardiac glycosides in regulating Na+/K+-ATPase. The cytotoxic effect of cardiac glycosides is discussed with respect to the apoptotic mechanisms possibly induced by these compounds. Novel strategies in cancer therapy based on cardiac glycosides are discussed as are possibilities for counteracting multidrug resistance by using cardiac

Název v anglickém jazyce

From Na+/K+-ATPase and Cardiac Glycosides to Cytotoxicity and Cancer Treatment

Popis výsledku anglicky

The cardiac glycosides are a group of compounds isolated from plants and some animals. They have been used in therapy for heart failure for many years. The cytotoxic effect of many cardiac glycosides has been demonstrated, but the mechanism of action isvery complicated and complex, and Na+/K+-ATPase surely plays a crucial role in it. On the other hand, Na+/K+-ATPase is regulated by many endogenous factors, such as hormones or FXYD proteins, whose role in regulating the cell cycle has been studied intensively. This review focuses on the role of Na+/K+-ATPase in regulating the cell growth, the cell cycle and the cell proliferation and on the involvement of cardiac glycosides in regulating Na+/K+-ATPase. The cytotoxic effect of cardiac glycosides is discussed with respect to the apoptotic mechanisms possibly induced by these compounds. Novel strategies in cancer therapy based on cardiac glycosides are discussed as are possibilities for counteracting multidrug resistance by using cardiac

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Anti-Cancer Agents in Medicinal Chemistry

ISSN

1871-5206

e-ISSN

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Svazek periodika

13

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

AE - Spojené arabské emiráty

Počet stran výsledku

19

Strana od-do

1069-1087

Kód UT WoS článku

000324249500013

EID výsledku v databázi Scopus

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