AQP4 tag single nucleotide polymorphisms in patients with traumatic brain injury
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F14%3A00061138" target="_blank" >RIV/00159816:_____/14:00061138 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1089/neu.2014.3347" target="_blank" >http://dx.doi.org/10.1089/neu.2014.3347</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1089/neu.2014.3347" target="_blank" >10.1089/neu.2014.3347</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
AQP4 tag single nucleotide polymorphisms in patients with traumatic brain injury
Popis výsledku v původním jazyce
Accumulating evidence suggests that the extent of brain injury and the clinical outcome after Traumatic Brain Injury (TBI) are modulated, to some degree, by genetic variants. Aquaporin-4 (AQP4) is the predominant water channel in the central nervous system and plays a critical role in controlling the water content of brain cells and the development of brain edema after TBI. We sought to investigate the influence of the AQP4 gene region on the patients' outcome after TBI by genotyping tag single nucleotide polymorphisms (SNPs) along AQP4 gene. A total of 363 TBI patients (19.6% female) were prospectively evaluated. Data including the Glasgow Coma Scale (GCS) scores at admission, the presence of intracranial haemorrhage and the 6-month Glasgow Outcome Scale (GOS) scores were collected. Seven tag single SNPs across AQP4 gene were identified based on the HapMap data. Using logistic regression analyses SNPs and haplotypes were tested for associations with 6-month GOS after adjusting for age
Název v anglickém jazyce
AQP4 tag single nucleotide polymorphisms in patients with traumatic brain injury
Popis výsledku anglicky
Accumulating evidence suggests that the extent of brain injury and the clinical outcome after Traumatic Brain Injury (TBI) are modulated, to some degree, by genetic variants. Aquaporin-4 (AQP4) is the predominant water channel in the central nervous system and plays a critical role in controlling the water content of brain cells and the development of brain edema after TBI. We sought to investigate the influence of the AQP4 gene region on the patients' outcome after TBI by genotyping tag single nucleotide polymorphisms (SNPs) along AQP4 gene. A total of 363 TBI patients (19.6% female) were prospectively evaluated. Data including the Glasgow Coma Scale (GCS) scores at admission, the presence of intracranial haemorrhage and the 6-month Glasgow Outcome Scale (GOS) scores were collected. Seven tag single SNPs across AQP4 gene were identified based on the HapMap data. Using logistic regression analyses SNPs and haplotypes were tested for associations with 6-month GOS after adjusting for age
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FH - Neurologie, neurochirurgie, neurovědy
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: Fakultní nemocnice u sv. Anny v Brně - Mezinárodní centrum klinického výzkumu (FNUSA - ICRC)</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of Neurotrauma
ISSN
0897-7151
e-ISSN
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Svazek periodika
31
Číslo periodika v rámci svazku
23
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
7
Strana od-do
1920-1926
Kód UT WoS článku
000345075500004
EID výsledku v databázi Scopus
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