"Liberation treatment" for chronic cerebrospinal venous insufficiency in multiple sclerosis: the truth will set you free

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F15%3A00062695" target="_blank" >RIV/00159816:_____/15:00062695 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1002/brb3.297" target="_blank" >http://dx.doi.org/10.1002/brb3.297</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/brb3.297" target="_blank" >10.1002/brb3.297</a>

Jazyk výsledku

angličtina

Název v původním jazyce

"Liberation treatment" for chronic cerebrospinal venous insufficiency in multiple sclerosis: the truth will set you free

Popis výsledku v původním jazyce

BackgroundChronic cerebrospinal venous insufficiency (CCSVI) has recently been introduced as a chronic state of impaired cerebral or cervical venous drainage that may be causally implicated in multiple sclerosis (MS) pathogenesis. Moreover, percutaneoustransluminal angioplasty of extracranial veins termed Liberation treatment has been proposed (based on nonrandomized data) as an alternative therapy for MS. Methods A comprehensive literature search was conducted to identify available published, peer-reviewed, clinical studies evaluating (1) the association of CCSVI with MS, (2) the reproducibility of proposed ultrasound criteria for CCSVI detection (3) the safety and efficacy of Liberation treatment in open-label and randomized-controlled trial (RCT) settings. Results There is substantial heterogeneity between ultrasound case-control studies investigating the association of CCSVI and MS. The majority of independent investigators failed to reproduce the initially reported high prevalenc

Název v anglickém jazyce

"Liberation treatment" for chronic cerebrospinal venous insufficiency in multiple sclerosis: the truth will set you free

Popis výsledku anglicky

BackgroundChronic cerebrospinal venous insufficiency (CCSVI) has recently been introduced as a chronic state of impaired cerebral or cervical venous drainage that may be causally implicated in multiple sclerosis (MS) pathogenesis. Moreover, percutaneoustransluminal angioplasty of extracranial veins termed Liberation treatment has been proposed (based on nonrandomized data) as an alternative therapy for MS. Methods A comprehensive literature search was conducted to identify available published, peer-reviewed, clinical studies evaluating (1) the association of CCSVI with MS, (2) the reproducibility of proposed ultrasound criteria for CCSVI detection (3) the safety and efficacy of Liberation treatment in open-label and randomized-controlled trial (RCT) settings. Results There is substantial heterogeneity between ultrasound case-control studies investigating the association of CCSVI and MS. The majority of independent investigators failed to reproduce the initially reported high prevalenc

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: Fakultní nemocnice u sv. Anny v Brně - Mezinárodní centrum klinického výzkumu (FNUSA - ICRC)</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Brain and Behavior

ISSN

2162-3279

e-ISSN

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Svazek periodika

5

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

"e00297"

Kód UT WoS článku

000349034700002

EID výsledku v databázi Scopus

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