Polymorphisms of the Peroxisome Proliferator-Activated Receptor-gamma (rs1801282) and its coactivator-1 (rs8192673) are associated with obesity indexes in subjects with type 2 diabetes mellitus

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F15%3A00063205" target="_blank" >RIV/00159816:_____/15:00063205 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1186/s12933-015-0197-0" target="_blank" >http://dx.doi.org/10.1186/s12933-015-0197-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12933-015-0197-0" target="_blank" >10.1186/s12933-015-0197-0</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Polymorphisms of the Peroxisome Proliferator-Activated Receptor-gamma (rs1801282) and its coactivator-1 (rs8192673) are associated with obesity indexes in subjects with type 2 diabetes mellitus

Popis výsledku v původním jazyce

The aim of this study was to clarify whether common single nucleotide polymorphisms (SNPs) of the Peroxisome Proliferator-Activated Receptor-gamma (PPAR-gamma) gene (rs1801282) and the Peroxisome Proliferator-Activated Receptor-gamma Coactivator-1 (PGC-1alpha) gene (rs8192673) are associated with obesity indexes (BMI, waist circumference) in subjects with type 2 diabetes mellitus (T2DM) in Caucasian population. The second aim was to find an association of both polymorphisms with T2DM. Methods: Two exonic SNPs of both genes rs1801282 of the PPAR-gamma gene and rs8192673 of the PGC-1 alpha gene) were genotyped in 881 unrelated Slovene subjects (Caucasians) with T2DM and in 348 subjects without T2DM (control subjects). Results: Female homozygotes with the CC genotype of the rs8192673 had higher waist circumference in comparison with subjects with other genotypes. Homozygotes (females, males) with wild allele (Pro) of the rs1801282 (Pro12Ala polymorphism) had higher waist circumference in

Název v anglickém jazyce

Polymorphisms of the Peroxisome Proliferator-Activated Receptor-gamma (rs1801282) and its coactivator-1 (rs8192673) are associated with obesity indexes in subjects with type 2 diabetes mellitus

Popis výsledku anglicky

The aim of this study was to clarify whether common single nucleotide polymorphisms (SNPs) of the Peroxisome Proliferator-Activated Receptor-gamma (PPAR-gamma) gene (rs1801282) and the Peroxisome Proliferator-Activated Receptor-gamma Coactivator-1 (PGC-1alpha) gene (rs8192673) are associated with obesity indexes (BMI, waist circumference) in subjects with type 2 diabetes mellitus (T2DM) in Caucasian population. The second aim was to find an association of both polymorphisms with T2DM. Methods: Two exonic SNPs of both genes rs1801282 of the PPAR-gamma gene and rs8192673 of the PGC-1 alpha gene) were genotyped in 881 unrelated Slovene subjects (Caucasians) with T2DM and in 348 subjects without T2DM (control subjects). Results: Female homozygotes with the CC genotype of the rs8192673 had higher waist circumference in comparison with subjects with other genotypes. Homozygotes (females, males) with wild allele (Pro) of the rs1801282 (Pro12Ala polymorphism) had higher waist circumference in

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

<a href="/cs/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: Fakultní nemocnice u sv. Anny v Brně - Mezinárodní centrum klinického výzkumu (FNUSA - ICRC)</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cardiovascular Diabetology

ISSN

1475-2840

e-ISSN

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Svazek periodika

14

Číslo periodika v rámci svazku

APR

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

42

Kód UT WoS článku

000354968200001

EID výsledku v databázi Scopus

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