MicroRNAs in Embryonic Stem Cells

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F15%3A00063639" target="_blank" >RIV/00159816:_____/15:00063639 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/15:00082538 RIV/65269705:_____/15:00063639

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/B9780124055445000071" target="_blank" >http://www.sciencedirect.com/science/article/pii/B9780124055445000071</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/B978-0-12-405544-5.00007-1" target="_blank" >10.1016/B978-0-12-405544-5.00007-1</a>

Jazyk výsledku

angličtina

Název v původním jazyce

MicroRNAs in Embryonic Stem Cells

Popis výsledku v původním jazyce

Stem cell research began in the 1950s with the study of teratocarcinomas. Stevens and Little [1] determined that these malignant germ-cell tumors comprise undifferentiated cell components (so-called embryonal carcinoma cells, or EC cells) that have the ability to form entirely new teratocarcinomas upon transplantation into experimental animals. In 1964, Lewis Kleinsmith and Barry Pierce demonstrated that a single EC cell is capable of multilineage differentiation as well as unlimited self-renewal-the two key characteristics of stem cells [2]. Later, mouse EC cell lines that can be stably propagated in vitro were established [3], and several EC cell lines were shown to form chimeras upon injection into mouse blastocysts [4]. Naturally, similar developmental properties of EC cells and early embryonic cells led to a search for a karyotypically stable counterpart of these cells. In the early 1980s, two groups simultaneously introduced the first pluripotent mouse embryonic stem cells to the scientific community.

Název v anglickém jazyce

MicroRNAs in Embryonic Stem Cells

Popis výsledku anglicky

Stem cell research began in the 1950s with the study of teratocarcinomas. Stevens and Little [1] determined that these malignant germ-cell tumors comprise undifferentiated cell components (so-called embryonal carcinoma cells, or EC cells) that have the ability to form entirely new teratocarcinomas upon transplantation into experimental animals. In 1964, Lewis Kleinsmith and Barry Pierce demonstrated that a single EC cell is capable of multilineage differentiation as well as unlimited self-renewal-the two key characteristics of stem cells [2]. Later, mouse EC cell lines that can be stably propagated in vitro were established [3], and several EC cell lines were shown to form chimeras upon injection into mouse blastocysts [4]. Naturally, similar developmental properties of EC cells and early embryonic cells led to a search for a karyotypically stable counterpart of these cells. In the early 1980s, two groups simultaneously introduced the first pluripotent mouse embryonic stem cells to the scientific community.

Druh

C - Kapitola v odborné knize

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

MicroRNA in Regenerative Medicine

ISBN

978-0-12-405544-5

Počet stran výsledku

30

Strana od-do

1-30

Počet stran knihy

1259

Název nakladatele

Elsevier

Místo vydání

London

Kód UT WoS kapitoly

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