Atopic phenotype associations with rs7927894 inter gene polymorphism on chromosome 11q13.5 in Czech adult patients with atopic dermatitis
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F15%3A00064031" target="_blank" >RIV/00159816:_____/15:00064031 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.15761/GOD.1000137" target="_blank" >http://dx.doi.org/10.15761/GOD.1000137</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.15761/GOD.1000137" target="_blank" >10.15761/GOD.1000137</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Atopic phenotype associations with rs7927894 inter gene polymorphism on chromosome 11q13.5 in Czech adult patients with atopic dermatitis
Popis výsledku v původním jazyce
We did not observe significant differences in genotype distribution and/or allelic frequencies between AD men and women in polymorphism rs792894. But, the CT genotype of polymorphism rs7927894 on chromosome 11q13.5 was more than 4times more frequently observed in AD women with elevated levels of the total IgE above 158 IU/ml. In AD men, a significant association of polymorphism rs7927894 on chromosome 11q13.5 with atopic phenotype/ predisposition was found: the genotypes CC and TT are 6 times more frequent in AD men with other atopic phenotype (asthma, atopic rhinitis) compared to AD men without it. The TT genotype of the polymorphism was 4 times more frequent in men with positive family history of atopic phenotypes.
Název v anglickém jazyce
Atopic phenotype associations with rs7927894 inter gene polymorphism on chromosome 11q13.5 in Czech adult patients with atopic dermatitis
Popis výsledku anglicky
We did not observe significant differences in genotype distribution and/or allelic frequencies between AD men and women in polymorphism rs792894. But, the CT genotype of polymorphism rs7927894 on chromosome 11q13.5 was more than 4times more frequently observed in AD women with elevated levels of the total IgE above 158 IU/ml. In AD men, a significant association of polymorphism rs7927894 on chromosome 11q13.5 with atopic phenotype/ predisposition was found: the genotypes CC and TT are 6 times more frequent in AD men with other atopic phenotype (asthma, atopic rhinitis) compared to AD men without it. The TT genotype of the polymorphism was 4 times more frequent in men with positive family history of atopic phenotypes.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
FO - Dermatovenerologie
OECD FORD obor
—
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů