Normal-Weight Central Obesity and Mortality Risk in Older Adults With Coronary Artery Disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F16%3A00064243" target="_blank" >RIV/00159816:_____/16:00064243 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.mayocp.2015.12.007" target="_blank" >http://dx.doi.org/10.1016/j.mayocp.2015.12.007</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.mayocp.2015.12.007" target="_blank" >10.1016/j.mayocp.2015.12.007</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Normal-Weight Central Obesity and Mortality Risk in Older Adults With Coronary Artery Disease

Popis výsledku v původním jazyce

Objective: To study the relationship between body mass index (BMI) and central obesity and mortality in elderly patients with coronary artery disease (CAD). Patients and Methods: We identified 7057 patients 65 years or older from 5 cohort studies assessing mortality risk using either waist circumference (WC) or waist-hip ratio (WHR) in patients with CAD from January 1, 1980, to December 31, 2008. Normal weight, overweight, and obesity were defined using standard BMI cutoffs. High WHR was defined as 0.85 or more for women and 0.90 or more for men. High WC was defined as 88 cm or more for women and 102 cm or more for men. Separate models examined WC or WHR in combination with BMI (6 categories each) as the primary predictor (referent = normal BMI and normal WC or WHR). Cox proportional hazards models investigated the relationship between these obesity categories and mortality. Results: Patients' mean age was 73.0 +/- 6.0 years (3741 [53%] women). The median censor time was 7.1 years. A normal BMI with central obesity (high WHR or high WC) demonstrated highest mortality risk (hazard ratio [HR], 1.29; 95% CI, 1.14-1.46; HR, 1.29; 95% CI, 1.12-1.50, respectively). High WHR was also predictive of mortality in the overall (HR, 2.14; 95% CI, 1.93-2.38) as well as in the sex-specific cohort. In the overall cohort, high WC was not predictive of mortality (HR, 1.04; 95% CI, 0.97-1.12); however, it predicted higher risk in men (HR, 1.12; 95% CI, 1.01-1.24). Conclusion: In older adults with CAD, normal-weight central obesity defined using either WHR or WC is associated with high mortality risk, highlighting a need to combine measures in adiposity-related risk assessment. (C) 2016 Mayo Foundation for Medical Education and Research

Název v anglickém jazyce

Normal-Weight Central Obesity and Mortality Risk in Older Adults With Coronary Artery Disease

Popis výsledku anglicky

Objective: To study the relationship between body mass index (BMI) and central obesity and mortality in elderly patients with coronary artery disease (CAD). Patients and Methods: We identified 7057 patients 65 years or older from 5 cohort studies assessing mortality risk using either waist circumference (WC) or waist-hip ratio (WHR) in patients with CAD from January 1, 1980, to December 31, 2008. Normal weight, overweight, and obesity were defined using standard BMI cutoffs. High WHR was defined as 0.85 or more for women and 0.90 or more for men. High WC was defined as 88 cm or more for women and 102 cm or more for men. Separate models examined WC or WHR in combination with BMI (6 categories each) as the primary predictor (referent = normal BMI and normal WC or WHR). Cox proportional hazards models investigated the relationship between these obesity categories and mortality. Results: Patients' mean age was 73.0 +/- 6.0 years (3741 [53%] women). The median censor time was 7.1 years. A normal BMI with central obesity (high WHR or high WC) demonstrated highest mortality risk (hazard ratio [HR], 1.29; 95% CI, 1.14-1.46; HR, 1.29; 95% CI, 1.12-1.50, respectively). High WHR was also predictive of mortality in the overall (HR, 2.14; 95% CI, 1.93-2.38) as well as in the sex-specific cohort. In the overall cohort, high WC was not predictive of mortality (HR, 1.04; 95% CI, 0.97-1.12); however, it predicted higher risk in men (HR, 1.12; 95% CI, 1.01-1.24). Conclusion: In older adults with CAD, normal-weight central obesity defined using either WHR or WC is associated with high mortality risk, highlighting a need to combine measures in adiposity-related risk assessment. (C) 2016 Mayo Foundation for Medical Education and Research

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Mayo Clinic Proceedings

ISSN

0025-6196

e-ISSN

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Svazek periodika

91

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

343-351

Kód UT WoS článku

000371248900013

EID výsledku v databázi Scopus

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