Endovascular reperfusion therapies for acute ischemic stroke: dissecting the evidence

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F16%3A00065035" target="_blank" >RIV/00159816:_____/16:00065035 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1586/14737175.2016.1168297" target="_blank" >http://dx.doi.org/10.1586/14737175.2016.1168297</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1586/14737175.2016.1168297" target="_blank" >10.1586/14737175.2016.1168297</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Endovascular reperfusion therapies for acute ischemic stroke: dissecting the evidence

Popis výsledku v původním jazyce

BACKGROUND: Ischemic stroke is a major cause of death and disability and intravenous thrombolysis has been the only approved acute reperfusion therapy (RT) for many years. METHODS: Seven randomized-controlled clinical trials (RCTs) evaluating the safety and efficacy of endovascular therapy in patients with acute ischemic stroke (AIS) due to emergent large vessel occlusion (ELVO) have been recently published. RESULTS: These studies have changed the treatment paradigm by establishing mechanical thrombectomy (MT) as the most effective acute stroke therapy for improving functional outcome in anterior circulation ELVO with a NNT of 6. CONCLUSIONS: The present review will critically evaluate the results of these RCTs and of the existing meta-analyses investigating the safety and efficacy of endovascular therapy for AIS. Points of debate such as acute stroke imaging, posterior circulation stroke and general anesthesia will be addressed. We will also discuss health policies aiming to increase the availability of endovascular treatment for stroke patients.

Název v anglickém jazyce

Endovascular reperfusion therapies for acute ischemic stroke: dissecting the evidence

Popis výsledku anglicky

BACKGROUND: Ischemic stroke is a major cause of death and disability and intravenous thrombolysis has been the only approved acute reperfusion therapy (RT) for many years. METHODS: Seven randomized-controlled clinical trials (RCTs) evaluating the safety and efficacy of endovascular therapy in patients with acute ischemic stroke (AIS) due to emergent large vessel occlusion (ELVO) have been recently published. RESULTS: These studies have changed the treatment paradigm by establishing mechanical thrombectomy (MT) as the most effective acute stroke therapy for improving functional outcome in anterior circulation ELVO with a NNT of 6. CONCLUSIONS: The present review will critically evaluate the results of these RCTs and of the existing meta-analyses investigating the safety and efficacy of endovascular therapy for AIS. Points of debate such as acute stroke imaging, posterior circulation stroke and general anesthesia will be addressed. We will also discuss health policies aiming to increase the availability of endovascular treatment for stroke patients.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Expert Review of Neurotherapeutics

ISSN

1473-7175

e-ISSN

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Svazek periodika

16

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

527-534

Kód UT WoS článku

000374950900008

EID výsledku v databázi Scopus

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