Contribution of prostaglandin E1 treatment in patients with critical limb ischemia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F16%3A00065356" target="_blank" >RIV/00159816:_____/16:00065356 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/16:00090353 RIV/62157124:16370/16:43874497

Výsledek na webu

<a href="http://www.ijcem.com/files/ijcem0014940.pdf" target="_blank" >http://www.ijcem.com/files/ijcem0014940.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Contribution of prostaglandin E1 treatment in patients with critical limb ischemia

Popis výsledku v původním jazyce

Background and aims: Peripheral arterial disease (PAD) in advanced stages has severe disabling complications. Major amputations (MA) and high mortality rates are common in patients with critical limb ischemia (CLI). Revascularization (interventional angioplasty or vascular surgery) appears to be possible in the large majority of cases if these patients are referred to a specialist earlier. Patients with CLI and lacking options for revascularization have worse prognosis. The purpose of this retrospective study was to investigate the impact of including prostaglandins in the treatment of patients with CLI lacking the possibility of revascularization. Method: This retrospective study cohort includes 67 patients (34 male and 33 female), mean age 71 +/- 10.7 years treated for CLI not suitable for revascularization. Prostaglandin E1 (alprostadil) was applied by intravenous perfusion with doses of 40 mu g twice a day for 2 weeks. Results: 23 patients (34.3%) underwent amputation and 17 patients (40.3%) died during the total follow-up period (01/2009-07/2014). Mortality rate was higher in patients who have undergone an amputation, in diabetics and in patients without statin medication. Conclusion: Patients with CLI lacking options for revascularization have despite treatment with prostanoids (alprostadil) a poor prognosis, with high amputation rate and increased mortality. Statin medication was a protective factor for survival.

Název v anglickém jazyce

Contribution of prostaglandin E1 treatment in patients with critical limb ischemia

Popis výsledku anglicky

Background and aims: Peripheral arterial disease (PAD) in advanced stages has severe disabling complications. Major amputations (MA) and high mortality rates are common in patients with critical limb ischemia (CLI). Revascularization (interventional angioplasty or vascular surgery) appears to be possible in the large majority of cases if these patients are referred to a specialist earlier. Patients with CLI and lacking options for revascularization have worse prognosis. The purpose of this retrospective study was to investigate the impact of including prostaglandins in the treatment of patients with CLI lacking the possibility of revascularization. Method: This retrospective study cohort includes 67 patients (34 male and 33 female), mean age 71 +/- 10.7 years treated for CLI not suitable for revascularization. Prostaglandin E1 (alprostadil) was applied by intravenous perfusion with doses of 40 mu g twice a day for 2 weeks. Results: 23 patients (34.3%) underwent amputation and 17 patients (40.3%) died during the total follow-up period (01/2009-07/2014). Mortality rate was higher in patients who have undergone an amputation, in diabetics and in patients without statin medication. Conclusion: Patients with CLI lacking options for revascularization have despite treatment with prostanoids (alprostadil) a poor prognosis, with high amputation rate and increased mortality. Statin medication was a protective factor for survival.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Clinical and Experimental Medicine

ISSN

1940-5901

e-ISSN

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Svazek periodika

9

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

3227-3231

Kód UT WoS článku

000374655200314

EID výsledku v databázi Scopus

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