Prevalence and Predictors of Early Heart Failure with Preserved Ejection Fraction in Patients with Paroxysmal Atrial Fibrillation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F17%3A00066885" target="_blank" >RIV/00159816:_____/17:00066885 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/17:00097556

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.cardfail.2017.04.002" target="_blank" >http://dx.doi.org/10.1016/j.cardfail.2017.04.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cardfail.2017.04.002" target="_blank" >10.1016/j.cardfail.2017.04.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Prevalence and Predictors of Early Heart Failure with Preserved Ejection Fraction in Patients with Paroxysmal Atrial Fibrillation

Popis výsledku v původním jazyce

Patients with atrial fibrillation (AF) have an increased risk of diastolic dysfunction and heart failure. The purpose of this study was to identify independent predictors of early (i.e., only exercise-induced) heart failure with preserved ejection fraction (HFpEF) and to describe the prevalence of early HFpEF among the patients with paroxysmal AF. METHODS AND RESULTS: One hundred patients with paroxysmal AF and preserved left ventricular ejection fraction (LVEF) underwent catheterization with left atrial pressure (LAP) measurements at rest and at the peak of arm exercise (LAP-exe). Based on resting and exercise LAP values, the patients were divided into three groups. Sixty-one patients had no evidence of HFpEF (LAP at rest LESS-THAN OR EQUAL TO15 mmHg, LAP-exe &lt;25 mmHg). Twenty-five subjects had early HFpEF (LAP at rest LESS-THAN OR EQUAL TO15 mmHg, LAP-exe GREATER-THAN OR EQUAL TO25 mmHg, prevalence 25%). Fourteen patients already had HFpEF at rest (LAP &gt;15 mmHg at rest). Multivariate exact logistic regression analysis identified age GREATER-THAN OR EQUAL TO58 years, LAP at rest GREATER-THAN OR EQUAL TO11 mmHg, and peak systolic mitral annular velocity LESS-THAN OR EQUAL TO9.3 cm/s to be independent predictors of early HFpEF. CONCLUSIONS: In patients with paroxysmal AF and preserved LVEF, there appears to be a clinically significant prevalence of early HFpEF.

Název v anglickém jazyce

Prevalence and Predictors of Early Heart Failure with Preserved Ejection Fraction in Patients with Paroxysmal Atrial Fibrillation

Popis výsledku anglicky

Patients with atrial fibrillation (AF) have an increased risk of diastolic dysfunction and heart failure. The purpose of this study was to identify independent predictors of early (i.e., only exercise-induced) heart failure with preserved ejection fraction (HFpEF) and to describe the prevalence of early HFpEF among the patients with paroxysmal AF. METHODS AND RESULTS: One hundred patients with paroxysmal AF and preserved left ventricular ejection fraction (LVEF) underwent catheterization with left atrial pressure (LAP) measurements at rest and at the peak of arm exercise (LAP-exe). Based on resting and exercise LAP values, the patients were divided into three groups. Sixty-one patients had no evidence of HFpEF (LAP at rest LESS-THAN OR EQUAL TO15 mmHg, LAP-exe &lt;25 mmHg). Twenty-five subjects had early HFpEF (LAP at rest LESS-THAN OR EQUAL TO15 mmHg, LAP-exe GREATER-THAN OR EQUAL TO25 mmHg, prevalence 25%). Fourteen patients already had HFpEF at rest (LAP &gt;15 mmHg at rest). Multivariate exact logistic regression analysis identified age GREATER-THAN OR EQUAL TO58 years, LAP at rest GREATER-THAN OR EQUAL TO11 mmHg, and peak systolic mitral annular velocity LESS-THAN OR EQUAL TO9.3 cm/s to be independent predictors of early HFpEF. CONCLUSIONS: In patients with paroxysmal AF and preserved LVEF, there appears to be a clinically significant prevalence of early HFpEF.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Cardiac Failure

ISSN

1071-9164

e-ISSN

—

Svazek periodika

23

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

558-562

Kód UT WoS článku

000406733500009

EID výsledku v databázi Scopus

—