Increased microcirculatory heterogeneity in patients with obstructive sleep apnea

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F17%3A00067147" target="_blank" >RIV/00159816:_____/17:00067147 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/17:00097612 RIV/65269705:_____/17:00067147

Výsledek na webu

<a href="http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0184291" target="_blank" >http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0184291</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pone.0184291" target="_blank" >10.1371/journal.pone.0184291</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Increased microcirculatory heterogeneity in patients with obstructive sleep apnea

Popis výsledku v původním jazyce

Obstructive sleep apnea (OSA) is the most common form of sleep disordered breathing and has been associated with major cardiovascular comorbidities. We hypothesized that the microcirculation is impaired in patients with OSA and that the magnitude of impairment correlates to OSA severity. Methods Subjects were consecutive patients scheduled for routine diagnostic polysomnography (PSG). OSA was defined by paradoxical rib cage movements together with abdominal excursions and by the apnea-hypopnea index (AHI) (events/hour; no apnea AHI&lt;5; mild apnea 5LESS-THAN OR EQUAL TOAHI&lt;15; moderate apnea 15LESS-THAN OR EQUAL TOAHI&lt;30; severe apnea AHI GREATER-THAN OR EQUAL TO30). Sidestream darkfield imaging was used to assess the sublingual microcirculation. Recordings of sublingual microcirculation (5 random sites) were performed before and after overnight PSG. Data are summarized as mean (+-SD); p values &lt;0.05 were considered statistically significant. Results Thirty-three consecutive patients were included. OSA was diagnosed in 16 subjects (4 moderate, 12 severe). There was no significant difference in microcirculation between subjects with moderate OSA and without OSA. However, compared to subjects without OSA, subjects with severe OSA (AHIGREATER-THAN OR EQUAL TO30) showed a significant decrease of microvascular flow index (-0.07+-0.17 vs. 0.08+-0.14; p = 0.02) and increase of microvascular flow index heterogeneity (0.06+-0.15 vs. -0.06+-0.11; p = 0.02) overnight. Multiple regression analysis (adjusted for age and gender) showed both decrease of flow and increase of flow heterogeneity associated with AHI (b = -0.41; F = 1.8; p = 0.04 and b = 0.43; F = 1.9; p = 0.03, respectively). Conclusion Acute overnight microcirculatory changes are observed in subjects with severe OSA characterized by decreased flow and increased flow heterogeneity.

Název v anglickém jazyce

Increased microcirculatory heterogeneity in patients with obstructive sleep apnea

Popis výsledku anglicky

Obstructive sleep apnea (OSA) is the most common form of sleep disordered breathing and has been associated with major cardiovascular comorbidities. We hypothesized that the microcirculation is impaired in patients with OSA and that the magnitude of impairment correlates to OSA severity. Methods Subjects were consecutive patients scheduled for routine diagnostic polysomnography (PSG). OSA was defined by paradoxical rib cage movements together with abdominal excursions and by the apnea-hypopnea index (AHI) (events/hour; no apnea AHI&lt;5; mild apnea 5LESS-THAN OR EQUAL TOAHI&lt;15; moderate apnea 15LESS-THAN OR EQUAL TOAHI&lt;30; severe apnea AHI GREATER-THAN OR EQUAL TO30). Sidestream darkfield imaging was used to assess the sublingual microcirculation. Recordings of sublingual microcirculation (5 random sites) were performed before and after overnight PSG. Data are summarized as mean (+-SD); p values &lt;0.05 were considered statistically significant. Results Thirty-three consecutive patients were included. OSA was diagnosed in 16 subjects (4 moderate, 12 severe). There was no significant difference in microcirculation between subjects with moderate OSA and without OSA. However, compared to subjects without OSA, subjects with severe OSA (AHIGREATER-THAN OR EQUAL TO30) showed a significant decrease of microvascular flow index (-0.07+-0.17 vs. 0.08+-0.14; p = 0.02) and increase of microvascular flow index heterogeneity (0.06+-0.15 vs. -0.06+-0.11; p = 0.02) overnight. Multiple regression analysis (adjusted for age and gender) showed both decrease of flow and increase of flow heterogeneity associated with AHI (b = -0.41; F = 1.8; p = 0.04 and b = 0.43; F = 1.9; p = 0.03, respectively). Conclusion Acute overnight microcirculatory changes are observed in subjects with severe OSA characterized by decreased flow and increased flow heterogeneity.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

PLoS ONE

ISSN

1932-6203

e-ISSN

—

Svazek periodika

12

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

"e0184291"

Kód UT WoS článku

000408816900046

EID výsledku v databázi Scopus

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