Spatial Navigation Impairment Is Associated with Alterations in Subcortical Intrinsic Activity in Mild Cognitive Impairment: A Resting-State fMRI Study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F17%3A00067248" target="_blank" >RIV/00159816:_____/17:00067248 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/17:10373877 RIV/00064203:_____/17:10373877

Výsledek na webu

<a href="http://dx.doi.org/10.1155/2017/6364314" target="_blank" >http://dx.doi.org/10.1155/2017/6364314</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2017/6364314" target="_blank" >10.1155/2017/6364314</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Spatial Navigation Impairment Is Associated with Alterations in Subcortical Intrinsic Activity in Mild Cognitive Impairment: A Resting-State fMRI Study

Popis výsledku v původním jazyce

Impairment of spatial navigation (SN) skills is one of the features of the Alzheimer&apos;s disease (AD) already at the stage of mild cognitive impairment (MCI). We used a computer-based battery of spatial navigation tests to measure the SN performance in 22 MCI patients as well as 21 normal controls (NC). In order to evaluate intrinsic activity in the subcortical regions that may play a role in SN, we measured ALFF, fALFF, and ReHo derived within 14 subcortical regions. We observed reductions of intrinsic activity in MCI patients. We also demonstrated that the MCI versus NC group difference can modulate activity-behavior relationship, that is, the correlation slopes between ReHo and allocentric SN task total errors were significantly different between NC and MCI groups in the right hippocampus (interaction F = 4 44, p = 0 05), pallidum (F = 8 97, p = 0 005), and thalamus (F = 5 95, p = 0 02), which were negative in NC (right hippocampus, r = -0 49; right pallidum, r = -0 50; right thalamus, r = -0 45; all p &lt; 0 05) but absent in MCI (right hippocampus, r = 0 21; right pallidum, r = 0 32; right thalamus r = 0 28; all p &gt; 0 2). These findings may provide a novel insight of the brain mechanism associated with SN impairment in MCI and indicated a stage specificity of brain-behavior correlation in dementia.

Název v anglickém jazyce

Spatial Navigation Impairment Is Associated with Alterations in Subcortical Intrinsic Activity in Mild Cognitive Impairment: A Resting-State fMRI Study

Popis výsledku anglicky

Impairment of spatial navigation (SN) skills is one of the features of the Alzheimer&apos;s disease (AD) already at the stage of mild cognitive impairment (MCI). We used a computer-based battery of spatial navigation tests to measure the SN performance in 22 MCI patients as well as 21 normal controls (NC). In order to evaluate intrinsic activity in the subcortical regions that may play a role in SN, we measured ALFF, fALFF, and ReHo derived within 14 subcortical regions. We observed reductions of intrinsic activity in MCI patients. We also demonstrated that the MCI versus NC group difference can modulate activity-behavior relationship, that is, the correlation slopes between ReHo and allocentric SN task total errors were significantly different between NC and MCI groups in the right hippocampus (interaction F = 4 44, p = 0 05), pallidum (F = 8 97, p = 0 005), and thalamus (F = 5 95, p = 0 02), which were negative in NC (right hippocampus, r = -0 49; right pallidum, r = -0 50; right thalamus, r = -0 45; all p &lt; 0 05) but absent in MCI (right hippocampus, r = 0 21; right pallidum, r = 0 32; right thalamus r = 0 28; all p &gt; 0 2). These findings may provide a novel insight of the brain mechanism associated with SN impairment in MCI and indicated a stage specificity of brain-behavior correlation in dementia.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Behavioural Neurology

ISSN

0953-4180

e-ISSN

—

Svazek periodika

2017

Číslo periodika v rámci svazku

2017

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

6364314

Kód UT WoS článku

000412005300001

EID výsledku v databázi Scopus

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