Higher visceral fat is associated with lower cerebral N-acetyl-aspartate ratios in middle-aged adults

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F17%3A00068393" target="_blank" >RIV/00159816:_____/17:00068393 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s11011-017-9961-z" target="_blank" >http://dx.doi.org/10.1007/s11011-017-9961-z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11011-017-9961-z" target="_blank" >10.1007/s11011-017-9961-z</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Higher visceral fat is associated with lower cerebral N-acetyl-aspartate ratios in middle-aged adults

Popis výsledku v původním jazyce

Excessive adipose tissue, particularly with a central distribution, consists of visceral fat, which is metabolically active and could impinge upon central nervous system functioning. The aim of the current study was to examine levels of visceral adiposity in relation to key cerebral metabolite ratios localized in the occipitoparietal grey matter. Seventy-three adults, aged between 40 and 60 years, underwent structural magnetic resonance imaging and single voxel H-1 Magnetic Resonance Spectroscopy (H-1 MRS). Visceral fat was assessed using Dual Energy X Ray Absorptiometry (DXA). Individuals with higher visceral fat mass and volume had significantly lower ratios of N-acetyl-aspartate to total creatine (phosphocreatine + creatine, PCr + Cr) (NAA/PCr + Cr) (beta = -0.29, p = 0.03, beta = -0.28, p = 0.04). They also had significantly higher ratios of myo-inositol to total creatine (mI/PCr + Cr ) (beta = 0.36, p = 0.01, beta = 0.36, p = 0.01). Visceral fat mass and volume were not significantly related to ratios of glutamate to total creatine (Glu/PCr + Cr). While future studies are necessary, these results indicate central adiposity is associated with metabolic changes that could impinge upon the central nervous system in middle age.

Název v anglickém jazyce

Higher visceral fat is associated with lower cerebral N-acetyl-aspartate ratios in middle-aged adults

Popis výsledku anglicky

Excessive adipose tissue, particularly with a central distribution, consists of visceral fat, which is metabolically active and could impinge upon central nervous system functioning. The aim of the current study was to examine levels of visceral adiposity in relation to key cerebral metabolite ratios localized in the occipitoparietal grey matter. Seventy-three adults, aged between 40 and 60 years, underwent structural magnetic resonance imaging and single voxel H-1 Magnetic Resonance Spectroscopy (H-1 MRS). Visceral fat was assessed using Dual Energy X Ray Absorptiometry (DXA). Individuals with higher visceral fat mass and volume had significantly lower ratios of N-acetyl-aspartate to total creatine (phosphocreatine + creatine, PCr + Cr) (NAA/PCr + Cr) (beta = -0.29, p = 0.03, beta = -0.28, p = 0.04). They also had significantly higher ratios of myo-inositol to total creatine (mI/PCr + Cr ) (beta = 0.36, p = 0.01, beta = 0.36, p = 0.01). Visceral fat mass and volume were not significantly related to ratios of glutamate to total creatine (Glu/PCr + Cr). While future studies are necessary, these results indicate central adiposity is associated with metabolic changes that could impinge upon the central nervous system in middle age.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

METABOLIC BRAIN DISEASE

ISSN

0885-7490

e-ISSN

—

Svazek periodika

32

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

727-733

Kód UT WoS článku

000400767700009

EID výsledku v databázi Scopus

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