Post-radiation cognitive inpairment and hippocampal neuronal depletion measured by in-vivo metabolic MR spectroscopy: Results of prospective investigational study
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F17%3A00068395" target="_blank" >RIV/00159816:_____/17:00068395 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1093/neuonc/nox036.170" target="_blank" >http://dx.doi.org/10.1093/neuonc/nox036.170</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/neuonc/nox036.170" target="_blank" >10.1093/neuonc/nox036.170</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Post-radiation cognitive inpairment and hippocampal neuronal depletion measured by in-vivo metabolic MR spectroscopy: Results of prospective investigational study
Popis výsledku v původním jazyce
Hippocampal radioinjury-mediated cognitive impairment is currently widely investigated in many preclinical and clinical trials. Further studying of hippocampal pathophysiological changes after radiation and its relation to memory alteration are still needed to enable critical evidence for introduction hippocampal sparing and/or drug intervention for preserving memory function. For confirmation of this concept, a deeper understanding of the correlations of imaging and functional changes is needed. The aim of this prospective study is to evaluate post-whole brain radiotherapy (WBRT) changes in hippocampal concentration of N-acetylaspartate (h-tNAA) as a marker of neuronal loss and to correlate it to neurocognitive dysfunction
Název v anglickém jazyce
Post-radiation cognitive inpairment and hippocampal neuronal depletion measured by in-vivo metabolic MR spectroscopy: Results of prospective investigational study
Popis výsledku anglicky
Hippocampal radioinjury-mediated cognitive impairment is currently widely investigated in many preclinical and clinical trials. Further studying of hippocampal pathophysiological changes after radiation and its relation to memory alteration are still needed to enable critical evidence for introduction hippocampal sparing and/or drug intervention for preserving memory function. For confirmation of this concept, a deeper understanding of the correlations of imaging and functional changes is needed. The aim of this prospective study is to evaluate post-whole brain radiotherapy (WBRT) changes in hippocampal concentration of N-acetylaspartate (h-tNAA) as a marker of neuronal loss and to correlate it to neurocognitive dysfunction
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
—
OECD FORD obor
30210 - Clinical neurology
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2017
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů