Vše

Co hledáte?

Vše
Projekty
Výsledky výzkumu
Subjekty

Rychlé hledání

  • Projekty podpořené TA ČR
  • Významné projekty
  • Projekty s nejvyšší státní podporou
  • Aktuálně běžící projekty

Chytré vyhledávání

  • Takto najdu konkrétní +slovo
  • Takto z výsledků -slovo zcela vynechám
  • “Takto můžu najít celou frázi”

Whole-body low-dose computed tomography in multiple myeloma staging: Superior diagnostic performance in the detection of bone lesions, vertebral compression fractures, rib fractures and extraskeletal findings compared to radiography with similar radiation exposure

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F17%3A00068982" target="_blank" >RIV/00159816:_____/17:00068982 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/00216208:11110/17:10362239 RIV/00064165:_____/17:10362239

  • Výsledek na webu

    <a href="https://www.spandidos-publications.com/10.3892/ol.2017.5723" target="_blank" >https://www.spandidos-publications.com/10.3892/ol.2017.5723</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3892/ol.2017.5723" target="_blank" >10.3892/ol.2017.5723</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Whole-body low-dose computed tomography in multiple myeloma staging: Superior diagnostic performance in the detection of bone lesions, vertebral compression fractures, rib fractures and extraskeletal findings compared to radiography with similar radiation exposure

  • Popis výsledku v původním jazyce

    The primary objective of the present prospective study was to compare the diagnostic performance of conventional radiography (CR) and whole-body low-dose computed tomography (WBLDCT) with a comparable radiation dose reconstructed using hybrid iterative reconstruction technique, in terms of the detection of bone lesions, skeletal fractures, vertebral compressions and extraskeletal findings. The secondary objective was to evaluate lesion attenuation in relation to its size. A total of 74 patients underwent same-day skeletal survey by CR and WBLDCT. In CR and WBLDCT, two readers assessed the number of osteolytic lesions at each region and stage according to the International Myeloma Working Group (IMWG) criteria. A single reader additionally assessed extraskeletal findings and their significance, the number of vertebral compressions and bone fractures. The radiation exposure was 2.7 +/- 0.9 mSv for WBLDCT and 2.5 +/- 0.9 mSv for CR (P= 0.054). CR detected bone involvement in 127 out of 486 regions (26%; P&lt; 0.0001), confirmed by WBLDCT. CR underestimated the disease stage in 16% and overestimated it in 8% of the patients (P= 0.0077). WBLDCT detected more rib fractures compared with CR (188 vs. 47; P&lt; 0.0001), vertebral compressions (93 vs. 67; P= 0.010) and extraskeletal findings (194 vs. 52; P&lt; 0.0001). There was no correlation observed between lesion size (&gt;= 5 mm) and its attenuation (r= -0.006; P= 0.93). The inter-observer agreement for the presence of osteolytic lesions was kappa= 0.76 for WBLDCT, and kappa= 0.55 for CR. The present study concluded that WBLDCT with hybrid iterative reconstruction technique demonstrates superiority to CR with an identical radiation dose in the detection of bone lesions, skeletal fractures, vertebral compressions and extraskeletal findings, which results in up-or downstaging in 24% patients according to the IMWG criteria. The attenuation of osteolytic lesions can be measured with the avoidance of the partial volume effect.

  • Název v anglickém jazyce

    Whole-body low-dose computed tomography in multiple myeloma staging: Superior diagnostic performance in the detection of bone lesions, vertebral compression fractures, rib fractures and extraskeletal findings compared to radiography with similar radiation exposure

  • Popis výsledku anglicky

    The primary objective of the present prospective study was to compare the diagnostic performance of conventional radiography (CR) and whole-body low-dose computed tomography (WBLDCT) with a comparable radiation dose reconstructed using hybrid iterative reconstruction technique, in terms of the detection of bone lesions, skeletal fractures, vertebral compressions and extraskeletal findings. The secondary objective was to evaluate lesion attenuation in relation to its size. A total of 74 patients underwent same-day skeletal survey by CR and WBLDCT. In CR and WBLDCT, two readers assessed the number of osteolytic lesions at each region and stage according to the International Myeloma Working Group (IMWG) criteria. A single reader additionally assessed extraskeletal findings and their significance, the number of vertebral compressions and bone fractures. The radiation exposure was 2.7 +/- 0.9 mSv for WBLDCT and 2.5 +/- 0.9 mSv for CR (P= 0.054). CR detected bone involvement in 127 out of 486 regions (26%; P&lt; 0.0001), confirmed by WBLDCT. CR underestimated the disease stage in 16% and overestimated it in 8% of the patients (P= 0.0077). WBLDCT detected more rib fractures compared with CR (188 vs. 47; P&lt; 0.0001), vertebral compressions (93 vs. 67; P= 0.010) and extraskeletal findings (194 vs. 52; P&lt; 0.0001). There was no correlation observed between lesion size (&gt;= 5 mm) and its attenuation (r= -0.006; P= 0.93). The inter-observer agreement for the presence of osteolytic lesions was kappa= 0.76 for WBLDCT, and kappa= 0.55 for CR. The present study concluded that WBLDCT with hybrid iterative reconstruction technique demonstrates superiority to CR with an identical radiation dose in the detection of bone lesions, skeletal fractures, vertebral compressions and extraskeletal findings, which results in up-or downstaging in 24% patients according to the IMWG criteria. The attenuation of osteolytic lesions can be measured with the avoidance of the partial volume effect.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    30204 - Oncology

Návaznosti výsledku

  • Projekt

  • Návaznosti

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Ostatní

  • Rok uplatnění

    2017

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Oncology Letters

  • ISSN

    1792-1074

  • e-ISSN

  • Svazek periodika

    13

  • Číslo periodika v rámci svazku

    4

  • Stát vydavatele periodika

    GR - Řecká republika

  • Počet stran výsledku

    5

  • Strana od-do

    2490-2494

  • Kód UT WoS článku

    000398514200071

  • EID výsledku v databázi Scopus