Ambulatory blood pressure monitoring and hypertension related cardiovascular risk in patients with rheumatoid arthritis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F17%3A00069906" target="_blank" >RIV/00159816:_____/17:00069906 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.openaccessjournals.com/articles/ambulatory-blood-pressure-monitoring-and-hypertension-related-cardiovascular-risk-in-patients-with-rheumatoid-arthritis-12223.html" target="_blank" >https://www.openaccessjournals.com/articles/ambulatory-blood-pressure-monitoring-and-hypertension-related-cardiovascular-risk-in-patients-with-rheumatoid-arthritis-12223.html</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4172/1758-4272.1000149" target="_blank" >10.4172/1758-4272.1000149</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Ambulatory blood pressure monitoring and hypertension related cardiovascular risk in patients with rheumatoid arthritis

Popis výsledku v původním jazyce

Background: To assess hypertension related cardiovascular risk parameters in patients with rheumatoid arthritis. To determine the effect of long-term treatment with corticosteroids, non-steroid antiinflammatory drugs, and methotrexate on diurnal BP variability. Material and methods: 60 patients with clinically stable rheumatoid arthritis and treated hypertension. Casual blood pressure measurement and 24-hour ambulatory blood pressure monitoring. Results: Mean casual systolic blood pressure 139.0 +- 14.6 mmHg, diastolic blood pressure 85.7 +- 6.5 mmHg, and heart rate 74.9 +- 7.2 beats.min-1. Mean 24-hour systolic blood pressure 129.0 +- 12.7 mmHg, diastolic blood pressure 77.6 +- 7.4 mmHg, and heart rate 73.9 +- 8.7 beats.min-1. Mean casual pulse pressure 54.7 +- 15.6 mmHg, and the mean 24-hour ambulatory pulse pressure 50.1 +- 11.0 mmHg. The mean morning surge of systolic blood pressure 35.3 +- 11.00 mmHg. The number of patients with increased short-term variability of their systolic blood pressure using the coefficient of variation 30 (50%). A number of systolic nondippers in the group were treated with corticosteroids and non-steroidal anti-inflammatory drugs 34% and 35%, respectively, and a number of excessive diastolic dippers in the group were treated with methotrexate 49%. Conclusions: Certain hypertension characteristics in patients with rheumatoid arthritis can increase cardiovascular risk: Higher pulse pressure, elevated levels of morning surge of systolic blood pressure, increased short-term 24-hour blood pressure variability, higher number of systolic nondippers treated with corticosteroids and non-steroidal anti-inflammatory drugs, and excessive diastolic dippers treated with methotrexate. In addition increased heart rate may contribute to higher cardiovascular risk.

Název v anglickém jazyce

Ambulatory blood pressure monitoring and hypertension related cardiovascular risk in patients with rheumatoid arthritis

Popis výsledku anglicky

Background: To assess hypertension related cardiovascular risk parameters in patients with rheumatoid arthritis. To determine the effect of long-term treatment with corticosteroids, non-steroid antiinflammatory drugs, and methotrexate on diurnal BP variability. Material and methods: 60 patients with clinically stable rheumatoid arthritis and treated hypertension. Casual blood pressure measurement and 24-hour ambulatory blood pressure monitoring. Results: Mean casual systolic blood pressure 139.0 +- 14.6 mmHg, diastolic blood pressure 85.7 +- 6.5 mmHg, and heart rate 74.9 +- 7.2 beats.min-1. Mean 24-hour systolic blood pressure 129.0 +- 12.7 mmHg, diastolic blood pressure 77.6 +- 7.4 mmHg, and heart rate 73.9 +- 8.7 beats.min-1. Mean casual pulse pressure 54.7 +- 15.6 mmHg, and the mean 24-hour ambulatory pulse pressure 50.1 +- 11.0 mmHg. The mean morning surge of systolic blood pressure 35.3 +- 11.00 mmHg. The number of patients with increased short-term variability of their systolic blood pressure using the coefficient of variation 30 (50%). A number of systolic nondippers in the group were treated with corticosteroids and non-steroidal anti-inflammatory drugs 34% and 35%, respectively, and a number of excessive diastolic dippers in the group were treated with methotrexate 49%. Conclusions: Certain hypertension characteristics in patients with rheumatoid arthritis can increase cardiovascular risk: Higher pulse pressure, elevated levels of morning surge of systolic blood pressure, increased short-term 24-hour blood pressure variability, higher number of systolic nondippers treated with corticosteroids and non-steroidal anti-inflammatory drugs, and excessive diastolic dippers treated with methotrexate. In addition increased heart rate may contribute to higher cardiovascular risk.

Druh

O - Ostatní výsledky

CEP obor

—

OECD FORD obor

30218 - General and internal medicine

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů