Evaluation and improvement of organic semiconductors' biocompatibility towards fibroblasts and cardiomyocytes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F18%3A00068623" target="_blank" >RIV/00159816:_____/18:00068623 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216305:26310/17:PU127108 RIV/68081707:_____/18:00491698 RIV/00216224:14310/18:00102399

Výsledek na webu

<a href="https://icrcis.fnusa.cz/cs/private-modular-files/ResultsForm/112/safarikova-2017-112.pdf" target="_blank" >https://icrcis.fnusa.cz/cs/private-modular-files/ResultsForm/112/safarikova-2017-112.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.snb.2017.12.108" target="_blank" >10.1016/j.snb.2017.12.108</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Evaluation and improvement of organic semiconductors' biocompatibility towards fibroblasts and cardiomyocytes

Popis výsledku v původním jazyce

The use of organic semiconductors in bioelectronic devices has received considerable attention over the past decade, since they have the potential to form an excellent biointerface for living cells and tissues. The aim was to determine multiple aspects of the biocompatibility of selected organic semiconductors with high conductivity and to further improve their potential for cell cultivation. Two representatives of low-molecular weight organic semiconductors triisopropylsilyethynyl pentacene (TIPS-Pentacene) and diketopyrrolopyrrole (DPP(TBFu)(2)) were selected together with two semiconducting organic polymers poly(3-hexylthiophene-2,5-diyl) (P3HT) and poly(3,4-ethylenedioxythiophene): poly(styrenesulfonate) (PEDOT:PSS). The stability of these materials in physiological environment and their wetting properties, which are preconditions for biocompatibility, were determined. TIPS-Pentacene, DPP(TBFu)(2) and P3HT were stable but PEDOT: PPS produced some leachates. Native TIPS-Pentacene, DPP(TBFu)(2) and P3HT exhibited lowered wettability. Their biocompatibility was studied by means of fibroblasts and differentiated cardiomyocytes. It was limited compared to standard cell culture plastics, thus coating of surface by proteins was applied. Among others collagen IV coating was shown to significantly improve biocompatibility of all tested organic semiconductors. Finally, cultures of spontaneously beating cardiomyocytes were established on TIPS-Pentacene, DPP(TBFu)(2), P3HT and PEDOT:PSS.

Název v anglickém jazyce

Evaluation and improvement of organic semiconductors' biocompatibility towards fibroblasts and cardiomyocytes

Popis výsledku anglicky

The use of organic semiconductors in bioelectronic devices has received considerable attention over the past decade, since they have the potential to form an excellent biointerface for living cells and tissues. The aim was to determine multiple aspects of the biocompatibility of selected organic semiconductors with high conductivity and to further improve their potential for cell cultivation. Two representatives of low-molecular weight organic semiconductors triisopropylsilyethynyl pentacene (TIPS-Pentacene) and diketopyrrolopyrrole (DPP(TBFu)(2)) were selected together with two semiconducting organic polymers poly(3-hexylthiophene-2,5-diyl) (P3HT) and poly(3,4-ethylenedioxythiophene): poly(styrenesulfonate) (PEDOT:PSS). The stability of these materials in physiological environment and their wetting properties, which are preconditions for biocompatibility, were determined. TIPS-Pentacene, DPP(TBFu)(2) and P3HT were stable but PEDOT: PPS produced some leachates. Native TIPS-Pentacene, DPP(TBFu)(2) and P3HT exhibited lowered wettability. Their biocompatibility was studied by means of fibroblasts and differentiated cardiomyocytes. It was limited compared to standard cell culture plastics, thus coating of surface by proteins was applied. Among others collagen IV coating was shown to significantly improve biocompatibility of all tested organic semiconductors. Finally, cultures of spontaneously beating cardiomyocytes were established on TIPS-Pentacene, DPP(TBFu)(2), P3HT and PEDOT:PSS.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

SENSORS AND ACTUATORS B-CHEMICAL

ISSN

0925-4005

e-ISSN

—

Svazek periodika

260

Číslo periodika v rámci svazku

May

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

8

Strana od-do

418-425

Kód UT WoS článku

000424884300050

EID výsledku v databázi Scopus

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