Clinical outcome of cardioembolic stroke treated by intravenous thrombolysis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F18%3A00068652" target="_blank" >RIV/00159816:_____/18:00068652 - isvavai.cz</a>

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/full/10.1111/ane.12880" target="_blank" >https://onlinelibrary.wiley.com/doi/full/10.1111/ane.12880</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/ane.12880" target="_blank" >10.1111/ane.12880</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Clinical outcome of cardioembolic stroke treated by intravenous thrombolysis

Popis výsledku v původním jazyce

Introduction Cardioembolic stroke (CS) in patients without thrombolytic treatment is associated with a worse clinical outcome and higher mortality compared to other types of stroke. The aim of this study was to determine the clinical outcome of CS in patients treated by intravenous thrombolysis (IVT). Material and methodology Data of patients from the SITS-EAST register (Safe Implementation of Treatments in Stroke) were analyzed in patients who received IVT treatment from 2000 to April 2014. The effect of the stroke etiology according to ICD-10 classification on outcome was analyzed using a univariate and multivariate analysis. The outcomes were assessed as follows: excellent clinical outcome (modified Rankin scale (mRS) 0-1) at 3months, the rate of symptomatic intracranial hemorrhage (sICH), mortality, and improvement at 24hours after IVT. Results Data of 13772 patients were analyzed. CS represented 30% of all strokes. The mean age of patients with CS, atherothrombotic stroke, lacunar stroke, and other stroke was 70.8, 66.7, 66.2, and 63.3years, respectively (P&lt;.001). Severity of stroke on admission by median NIHSS score was 13 points in patients with CS, 12 points - in atherothrombotic stroke, 7 points - in lacunar stroke, and 10 pointsin other stroke types (P&lt;.001). No difference in mortality was detected among atherothrombotic and CS; however, atherothrombotic strokes had higher odds of sICH [OR=1.63 (95% CI: 1.07-2.47), P=.023], lower odds of early improvement [OR=0.79 (95% CI: 0.72-0.86), P&lt;.001], and excellent clinical outcome [OR=0.77 (95% CI: 0.67-0.87), P&lt;.001] compared with CS. Conclusions Cardioembolic strokes are not associated with increased mortality. Patients with CS are less likely to have sICH and have better outcome after IVT.

Název v anglickém jazyce

Clinical outcome of cardioembolic stroke treated by intravenous thrombolysis

Popis výsledku anglicky

Introduction Cardioembolic stroke (CS) in patients without thrombolytic treatment is associated with a worse clinical outcome and higher mortality compared to other types of stroke. The aim of this study was to determine the clinical outcome of CS in patients treated by intravenous thrombolysis (IVT). Material and methodology Data of patients from the SITS-EAST register (Safe Implementation of Treatments in Stroke) were analyzed in patients who received IVT treatment from 2000 to April 2014. The effect of the stroke etiology according to ICD-10 classification on outcome was analyzed using a univariate and multivariate analysis. The outcomes were assessed as follows: excellent clinical outcome (modified Rankin scale (mRS) 0-1) at 3months, the rate of symptomatic intracranial hemorrhage (sICH), mortality, and improvement at 24hours after IVT. Results Data of 13772 patients were analyzed. CS represented 30% of all strokes. The mean age of patients with CS, atherothrombotic stroke, lacunar stroke, and other stroke was 70.8, 66.7, 66.2, and 63.3years, respectively (P&lt;.001). Severity of stroke on admission by median NIHSS score was 13 points in patients with CS, 12 points - in atherothrombotic stroke, 7 points - in lacunar stroke, and 10 pointsin other stroke types (P&lt;.001). No difference in mortality was detected among atherothrombotic and CS; however, atherothrombotic strokes had higher odds of sICH [OR=1.63 (95% CI: 1.07-2.47), P=.023], lower odds of early improvement [OR=0.79 (95% CI: 0.72-0.86), P&lt;.001], and excellent clinical outcome [OR=0.77 (95% CI: 0.67-0.87), P&lt;.001] compared with CS. Conclusions Cardioembolic strokes are not associated with increased mortality. Patients with CS are less likely to have sICH and have better outcome after IVT.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta neurologica Scandinavica

ISSN

0001-6314

e-ISSN

—

Svazek periodika

137

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

347-355

Kód UT WoS článku

000424092700010

EID výsledku v databázi Scopus

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