Influence of dose, gender, and cigarette smoking on clozapine plasma concentrations

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F18%3A00068806" target="_blank" >RIV/00159816:_____/18:00068806 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/18:00103968 RIV/65269705:_____/18:00068806

Výsledek na webu

<a href="https://www.dovepress.com/influence-of-dose-gender-and-cigarette-smoking-on-clozapine-plasma-con-peer-reviewed-fulltext-article-NDT" target="_blank" >https://www.dovepress.com/influence-of-dose-gender-and-cigarette-smoking-on-clozapine-plasma-con-peer-reviewed-fulltext-article-NDT</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2147/NDT.S163839" target="_blank" >10.2147/NDT.S163839</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Influence of dose, gender, and cigarette smoking on clozapine plasma concentrations

Popis výsledku v původním jazyce

Introduction: Therapeutic drug monitoring (TDM) of clozapine is a very useful method for verifying both the correct intake and the interindividual variability of its metabolism, thereby avoiding the risk of toxicity. The purposes of this paper were to discover how many patients using clozapine in common clinical practice have clozapine plasma concentration (PC) levels in the proposed reference range and to identify factors that influence clozapine PC levels. Methods: Our study included 100 inpatients (diagnosed with schizophrenia or schizoaffective disorder) taking standard doses of clozapine (100-700 mg/day). Clozapine concentration was measured by high-performance liquid chromatography. Correlations between doses and PC levels and the influence of smoking and gender on clozapine PC levels were calculated. Results: A large number of the patients (67%) had PC levels outside the proposed reference range. The clozapine PC levels were influenced by dose, gender, and cigarette smoking. Conclusion: The correlations between dose, gender, and cigarette smoking and clozapine PC levels highlighted by our study overlap other research. It was surprising to find such a large number of patients with clozapine PC levels outside the therapeutic range. This result suggests the importance of clozapine TDM due to misunderstood inter-and/or intraindividual variability or misestimated partial therapeutic compliance.

Název v anglickém jazyce

Influence of dose, gender, and cigarette smoking on clozapine plasma concentrations

Popis výsledku anglicky

Introduction: Therapeutic drug monitoring (TDM) of clozapine is a very useful method for verifying both the correct intake and the interindividual variability of its metabolism, thereby avoiding the risk of toxicity. The purposes of this paper were to discover how many patients using clozapine in common clinical practice have clozapine plasma concentration (PC) levels in the proposed reference range and to identify factors that influence clozapine PC levels. Methods: Our study included 100 inpatients (diagnosed with schizophrenia or schizoaffective disorder) taking standard doses of clozapine (100-700 mg/day). Clozapine concentration was measured by high-performance liquid chromatography. Correlations between doses and PC levels and the influence of smoking and gender on clozapine PC levels were calculated. Results: A large number of the patients (67%) had PC levels outside the proposed reference range. The clozapine PC levels were influenced by dose, gender, and cigarette smoking. Conclusion: The correlations between dose, gender, and cigarette smoking and clozapine PC levels highlighted by our study overlap other research. It was surprising to find such a large number of patients with clozapine PC levels outside the therapeutic range. This result suggests the importance of clozapine TDM due to misunderstood inter-and/or intraindividual variability or misestimated partial therapeutic compliance.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30215 - Psychiatry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neuropsychiatric disease and treatment

ISSN

1178-2021

e-ISSN

—

Svazek periodika

14

Číslo periodika v rámci svazku

JUN 2018

Stát vydavatele periodika

NZ - Nový Zéland

Počet stran výsledku

9

Strana od-do

1535-1543

Kód UT WoS článku

000435877800001

EID výsledku v databázi Scopus

2-s2.0-85048719752