White matter alterations in Parkinson's disease with normal cognition precede grey matter atrophy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F18%3A00068984" target="_blank" >RIV/00159816:_____/18:00068984 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14740/18:00105511

Výsledek na webu

<a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0187939" target="_blank" >https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0187939</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pone.0187939" target="_blank" >10.1371/journal.pone.0187939</a>

Jazyk výsledku

angličtina

Název v původním jazyce

White matter alterations in Parkinson's disease with normal cognition precede grey matter atrophy

Popis výsledku v původním jazyce

Introduction While progressive MRI brain changes characterize advanced Parkinson&apos;s disease (PD), little has been discovered about structural alterations in the earliest phase of the disease, i.e. in patients with motor symptoms and with normal cognition. Our study aimed to detect grey matter (GM) and white matter (WM) changes in PD patients without cognitive impairment. Methods Twenty PD patients and twenty-one healthy controls (HC) were tested for attention, executive function, working memory, and visuospatial and language domains. High-resolution T1-weighted and 60 directional diffusion-weighted 3T MRI images were acquired. The cortical, deep GM and WM volumes and density, as well as the diffusion properties of WM, were calculated. Analyses were repeated on data flipped to the side of the disease origin. Results PD patients did not show any significant differences from HC in cognitive functioning or in brain volumes. Decreased GM intensity was found in the left superior parietal lobe in the right (p&lt;0.02) and left (p&lt;0.01) flipped data. The analysis of original, un-flipped data demonstrated elevated axial diffusivity (p&lt;0.01) in the superior and anterior corona radiata, internal capsule, and external capsule in the left hemisphere of PD relative to HC, while higher mean and radial diffusivity were discovered in the right (p&lt;0.02 and p&lt;0.03, respectively) and left (p&lt;0.02 and p&lt;0.02, respectively) in the fronto-temporal WMutilizing flipped data. Conclusions PD patients without cognitive impairment and GM atrophy demonstrated widespread alterations of WM microstructure. Thus, WM impairment in PD might be a sensitive sign preceding the neuronal loss in associated GM regions.

Název v anglickém jazyce

White matter alterations in Parkinson's disease with normal cognition precede grey matter atrophy

Popis výsledku anglicky

Introduction While progressive MRI brain changes characterize advanced Parkinson&apos;s disease (PD), little has been discovered about structural alterations in the earliest phase of the disease, i.e. in patients with motor symptoms and with normal cognition. Our study aimed to detect grey matter (GM) and white matter (WM) changes in PD patients without cognitive impairment. Methods Twenty PD patients and twenty-one healthy controls (HC) were tested for attention, executive function, working memory, and visuospatial and language domains. High-resolution T1-weighted and 60 directional diffusion-weighted 3T MRI images were acquired. The cortical, deep GM and WM volumes and density, as well as the diffusion properties of WM, were calculated. Analyses were repeated on data flipped to the side of the disease origin. Results PD patients did not show any significant differences from HC in cognitive functioning or in brain volumes. Decreased GM intensity was found in the left superior parietal lobe in the right (p&lt;0.02) and left (p&lt;0.01) flipped data. The analysis of original, un-flipped data demonstrated elevated axial diffusivity (p&lt;0.01) in the superior and anterior corona radiata, internal capsule, and external capsule in the left hemisphere of PD relative to HC, while higher mean and radial diffusivity were discovered in the right (p&lt;0.02 and p&lt;0.03, respectively) and left (p&lt;0.02 and p&lt;0.02, respectively) in the fronto-temporal WMutilizing flipped data. Conclusions PD patients without cognitive impairment and GM atrophy demonstrated widespread alterations of WM microstructure. Thus, WM impairment in PD might be a sensitive sign preceding the neuronal loss in associated GM regions.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

PLoS ONE

ISSN

1932-6203

e-ISSN

—

Svazek periodika

13

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

15

Strana od-do

—

Kód UT WoS článku

000419403800009

EID výsledku v databázi Scopus

—