Learning to control tissue damage while fighting Aspergillus

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F18%3A00070445" target="_blank" >RIV/00159816:_____/18:00070445 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00159816:_____/19:00070445

Výsledek na webu

<a href="http://dx.doi.org/10.1093/mmy/myy053" target="_blank" >http://dx.doi.org/10.1093/mmy/myy053</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/mmy/myy053" target="_blank" >10.1093/mmy/myy053</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Learning to control tissue damage while fighting Aspergillus

Popis výsledku v původním jazyce

Aspergillus moulds are increasingly being recognised as significant human pathogens that can cause life-threatening infections in the context of host immune dysregulation, particularly in the lung. It is now clear that there is a close relationship between infection susceptibility and the fine regulation of pulmonary immunity and inflammation. While the contribution of IL-17/Th17 responses to both physiological and pathological lung inflammation is now well established, the cellular interactions, soluble factors, and signalling pathways that determine Th17 cell responses to fungal infection remain unclear. Here, we identify potential key mediators of fungus-DC-T cell interactions in the respiratory tract, with a focus on the DC-derived cytokines thought to exert a major influence on generation of pathological Th17 cells. We review recent data indicating a crucial role for Aspergillus-induced autophagy in lung DCs on subsequent T-cell polarization and modulation of &apos;stemness&apos;, which appears critical for avoiding pathological lung inflammation and promoting disease resolution.

Název v anglickém jazyce

Learning to control tissue damage while fighting Aspergillus

Popis výsledku anglicky

Aspergillus moulds are increasingly being recognised as significant human pathogens that can cause life-threatening infections in the context of host immune dysregulation, particularly in the lung. It is now clear that there is a close relationship between infection susceptibility and the fine regulation of pulmonary immunity and inflammation. While the contribution of IL-17/Th17 responses to both physiological and pathological lung inflammation is now well established, the cellular interactions, soluble factors, and signalling pathways that determine Th17 cell responses to fungal infection remain unclear. Here, we identify potential key mediators of fungus-DC-T cell interactions in the respiratory tract, with a focus on the DC-derived cytokines thought to exert a major influence on generation of pathological Th17 cells. We review recent data indicating a crucial role for Aspergillus-induced autophagy in lung DCs on subsequent T-cell polarization and modulation of &apos;stemness&apos;, which appears critical for avoiding pathological lung inflammation and promoting disease resolution.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30303 - Infectious Diseases

Projekt

<a href="/cs/project/EF15_003%2F0000492" target="_blank" >EF15_003/0000492: Mapování molekulární podstaty procesů stárnutí pro vývoj nových léčebných metod</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Medical mycology

ISSN

1369-3786

e-ISSN

—

Svazek periodika

57

Číslo periodika v rámci svazku

April

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

"S189"-"S195"

Kód UT WoS článku

000463726800013

EID výsledku v databázi Scopus

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