Intervertebral disc penetration by antibiotics used prophylactically in spinal surgery: implications for the current standards and treatment of disc infections

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F19%3A00070540" target="_blank" >RIV/00159816:_____/19:00070540 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14740/19:00109487 RIV/65269705:_____/19:00070540

Výsledek na webu

<a href="https://link.springer.com/content/pdf/10.1007/s00586-018-5838-z.pdf" target="_blank" >https://link.springer.com/content/pdf/10.1007/s00586-018-5838-z.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00586-018-5838-z" target="_blank" >10.1007/s00586-018-5838-z</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Intervertebral disc penetration by antibiotics used prophylactically in spinal surgery: implications for the current standards and treatment of disc infections

Popis výsledku v původním jazyce

PurposeThe presence of Propionibacterium acnes in a substantial component of resected disc specimens obtained from patients undergoing discectomy or microdiscectomy has led to the suggestion that this prominent human skin and oral commensal may exacerbate the pathology of degenerative disc disease. This hypothesis, therefore, raises the exciting possibility that antibiotics could play an important role in treating this debilitating condition. To date, however, little information about antibiotic penetration into the intervertebral disc is available. MethodsIntervertebral disc tissue obtained from 54 microdiscectomy patients given prophylactic cefazolin (n=25), clindamycin (n=17) or vancomycin (n=12) was assayed by high-performance liquid chromatography, with cefaclor as an internal standard, to determine the concentration of antibiotic penetrating into the disc tissue.ResultsIntervertebral disc tissues from patients receiving the positively charged antibiotic clindamycin contained a significantly greater percentage of the antibacterial dose than the tissue from patients receiving negatively charged cefazolin (P&lt;0.0001) and vancomycin, which has a slight positive charge (P&lt;0.0001).Conclusion Positively charged antibiotics appear more appropriate for future studies investigating potential options for the treatment of low-virulence disc infections. Graphical abstract: These slides can be retrieved under Electronic Supplementary Material.

Název v anglickém jazyce

Intervertebral disc penetration by antibiotics used prophylactically in spinal surgery: implications for the current standards and treatment of disc infections

Popis výsledku anglicky

PurposeThe presence of Propionibacterium acnes in a substantial component of resected disc specimens obtained from patients undergoing discectomy or microdiscectomy has led to the suggestion that this prominent human skin and oral commensal may exacerbate the pathology of degenerative disc disease. This hypothesis, therefore, raises the exciting possibility that antibiotics could play an important role in treating this debilitating condition. To date, however, little information about antibiotic penetration into the intervertebral disc is available. MethodsIntervertebral disc tissue obtained from 54 microdiscectomy patients given prophylactic cefazolin (n=25), clindamycin (n=17) or vancomycin (n=12) was assayed by high-performance liquid chromatography, with cefaclor as an internal standard, to determine the concentration of antibiotic penetrating into the disc tissue.ResultsIntervertebral disc tissues from patients receiving the positively charged antibiotic clindamycin contained a significantly greater percentage of the antibacterial dose than the tissue from patients receiving negatively charged cefazolin (P&lt;0.0001) and vancomycin, which has a slight positive charge (P&lt;0.0001).Conclusion Positively charged antibiotics appear more appropriate for future studies investigating potential options for the treatment of low-virulence disc infections. Graphical abstract: These slides can be retrieved under Electronic Supplementary Material.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30211 - Orthopaedics

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Spine Journal

ISSN

0940-6719

e-ISSN

—

Svazek periodika

28

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

783-791

Kód UT WoS článku

000463673200018

EID výsledku v databázi Scopus

2-s2.0-85057581239