Cardiopulmonary exercise testing for identification of patients with hyperventilation syndrome

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F19%3A00070541" target="_blank" >RIV/00159816:_____/19:00070541 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/19:00109665 RIV/65269705:_____/19:00070541

Výsledek na webu

<a href="https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0215997&type=printable" target="_blank" >https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0215997&type=printable</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pone.0215997" target="_blank" >10.1371/journal.pone.0215997</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cardiopulmonary exercise testing for identification of patients with hyperventilation syndrome

Popis výsledku v původním jazyce

Introduction Measurement of ventilatory efficiency, defined as minute ventilation per unit carbon dioxide production (V-E/VCO2), by cardiopulmonary exercise testing (CPET) has been proposed as a screen for hyperventilation syndrome (HVS). However, increased V-E/VCO2 may be associated with other disorders which need to be distinguished from HVS. A more specific marker of HVS by CPET would be clinically useful. We hypothesized ventilatory control during exercise is abnormal in patients with HVS. Methods Patients who underwent CPET from years 2015 through 2017 were retrospectively identified and formed the study group. HVS was defined as dyspnea with respiratory alkalosis (pH &gt;7.45) at peak exercise with absence of acute or chronic respiratory, heart or psychiatric disease. Healthy patients were selected as controls. For comparison the Student t-test or Mann-Whitney U test were used. Data are summarized as mean +/- SD or median (IQR); p&lt;0.05 was considered significant. Results Twenty-nine patients with HVS were identified and 29 control subjects were selected. At rest, end-tidal carbon dioxide (PETCO2) was 27 mmHg (25-30) for HVS patients vs. 30 mmHg (28-32); in controls (p = 0.05). At peak exercise PETCO2 was also significantly lower (27 +/- 4 mmHg vs. 35 +/- 4 mmHg; p&lt; 0.01) and V-E/VCO2 higher ((38 (35-43) vs. 31 (27-34); p&lt; 0.01)) in patients with HVS. In contrast to controls, there were minimal changes of PETCO2 (0.50 +/- 5.26 mmHg vs. 6.2 +/- 4.6 mmHg; p&lt; 0.01) and V-E/VCO2 ((0.17 (-4.24-6.02) vs. -6.6 (-11.4-(-2.8)); p&lt; 0.01)) during exercise in patients with HVS. The absence of V-E/VCO2 and PETCO2 change during exercise was specific for HVS (83% and 93%, respectively). Conclusion Absence of V-E/VCO2 and PETCO2 change during exercise may identify patients with HVS.

Název v anglickém jazyce

Cardiopulmonary exercise testing for identification of patients with hyperventilation syndrome

Popis výsledku anglicky

Introduction Measurement of ventilatory efficiency, defined as minute ventilation per unit carbon dioxide production (V-E/VCO2), by cardiopulmonary exercise testing (CPET) has been proposed as a screen for hyperventilation syndrome (HVS). However, increased V-E/VCO2 may be associated with other disorders which need to be distinguished from HVS. A more specific marker of HVS by CPET would be clinically useful. We hypothesized ventilatory control during exercise is abnormal in patients with HVS. Methods Patients who underwent CPET from years 2015 through 2017 were retrospectively identified and formed the study group. HVS was defined as dyspnea with respiratory alkalosis (pH &gt;7.45) at peak exercise with absence of acute or chronic respiratory, heart or psychiatric disease. Healthy patients were selected as controls. For comparison the Student t-test or Mann-Whitney U test were used. Data are summarized as mean +/- SD or median (IQR); p&lt;0.05 was considered significant. Results Twenty-nine patients with HVS were identified and 29 control subjects were selected. At rest, end-tidal carbon dioxide (PETCO2) was 27 mmHg (25-30) for HVS patients vs. 30 mmHg (28-32); in controls (p = 0.05). At peak exercise PETCO2 was also significantly lower (27 +/- 4 mmHg vs. 35 +/- 4 mmHg; p&lt; 0.01) and V-E/VCO2 higher ((38 (35-43) vs. 31 (27-34); p&lt; 0.01)) in patients with HVS. In contrast to controls, there were minimal changes of PETCO2 (0.50 +/- 5.26 mmHg vs. 6.2 +/- 4.6 mmHg; p&lt; 0.01) and V-E/VCO2 ((0.17 (-4.24-6.02) vs. -6.6 (-11.4-(-2.8)); p&lt; 0.01)) during exercise in patients with HVS. The absence of V-E/VCO2 and PETCO2 change during exercise was specific for HVS (83% and 93%, respectively). Conclusion Absence of V-E/VCO2 and PETCO2 change during exercise may identify patients with HVS.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10700 - Other natural sciences

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

PLoS ONE

ISSN

1932-6203

e-ISSN

—

Svazek periodika

14

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

13

Strana od-do

"e0215997"

Kód UT WoS článku

000465223900061

EID výsledku v databázi Scopus

2-s2.0-85065236491