Impairment of brain functions in Parkinson's disease reflected by alterations in neural connectivity in EEG studies: A viewpoint

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F19%3A00070694" target="_blank" >RIV/00159816:_____/19:00070694 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14740/19:00108608

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1388245718313762?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1388245718313762?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.clinph.2018.11.013" target="_blank" >10.1016/j.clinph.2018.11.013</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Impairment of brain functions in Parkinson's disease reflected by alterations in neural connectivity in EEG studies: A viewpoint

Popis výsledku v původním jazyce

Clinical symptoms of Parkinson&apos;s disease (PD) are accompanied by pathological phenomena detected locally in the basal ganglia (BG) as changes in local field potentials (LFPs) and also in cortical regions by electroencephalography (EEG). The literature published mainly between 2000 and 2017 was reviewed with an emphasis on approaches emerging after 2000, in particular on oscillatory dynamics, connectivity studies, and deep brain stimulation. Eighty-five articles were reviewed. The main observations were a general slowing of background activity, excessive synchronization of beta activity, and disturbed movement-related gamma oscillations in the BG and in the cortico-subcortical and cortico-cortical motor loops, suppressible by dopaminergic medication as well as by high-frequency deep brain stimulation (DBS). Non-motor symptoms are related mainly to changes in the alpha frequency range. EEG parameters can be useful in defining the risk of dementia in PD. Further progress was reported recently using advanced analytical technologies and high-performance computing (graph theory). Detailed knowledge of LFPs in PD enabled progress particularly in DBS therapy, which requires optimizing the clinical effect and minimizing adverse side effects. The neurocognitive networks and their dysfunction in PD and DBS therapy are promising targets for future research. (C) 2018 International Federation of Clinical Neurophysiology. Published by Elsevier B.V.

Název v anglickém jazyce

Impairment of brain functions in Parkinson's disease reflected by alterations in neural connectivity in EEG studies: A viewpoint

Popis výsledku anglicky

Clinical symptoms of Parkinson&apos;s disease (PD) are accompanied by pathological phenomena detected locally in the basal ganglia (BG) as changes in local field potentials (LFPs) and also in cortical regions by electroencephalography (EEG). The literature published mainly between 2000 and 2017 was reviewed with an emphasis on approaches emerging after 2000, in particular on oscillatory dynamics, connectivity studies, and deep brain stimulation. Eighty-five articles were reviewed. The main observations were a general slowing of background activity, excessive synchronization of beta activity, and disturbed movement-related gamma oscillations in the BG and in the cortico-subcortical and cortico-cortical motor loops, suppressible by dopaminergic medication as well as by high-frequency deep brain stimulation (DBS). Non-motor symptoms are related mainly to changes in the alpha frequency range. EEG parameters can be useful in defining the risk of dementia in PD. Further progress was reported recently using advanced analytical technologies and high-performance computing (graph theory). Detailed knowledge of LFPs in PD enabled progress particularly in DBS therapy, which requires optimizing the clinical effect and minimizing adverse side effects. The neurocognitive networks and their dysfunction in PD and DBS therapy are promising targets for future research. (C) 2018 International Federation of Clinical Neurophysiology. Published by Elsevier B.V.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/NV16-33798A" target="_blank" >NV16-33798A: Modulace funkční konektivity kortikálních sítí vlivem STN DBS</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Neurophysiology

ISSN

1388-2457

e-ISSN

—

Svazek periodika

130

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

239-247

Kód UT WoS článku

000456164600006

EID výsledku v databázi Scopus

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