Vowel Articulation Dynamic Stability Related to Parkinson's Disease Rating Features: Male Dataset

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F19%3A00070827" target="_blank" >RIV/00159816:_____/19:00070827 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216305:26220/19:PU129487 RIV/65269705:_____/19:00070827 RIV/00216224:14740/19:00108466

Výsledek na webu

<a href="https://www.worldscientific.com/doi/pdf/10.1142/S0129065718500375" target="_blank" >https://www.worldscientific.com/doi/pdf/10.1142/S0129065718500375</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1142/S0129065718500375" target="_blank" >10.1142/S0129065718500375</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Vowel Articulation Dynamic Stability Related to Parkinson's Disease Rating Features: Male Dataset

Popis výsledku v původním jazyce

Neurodegenerative pathologies as Parkinson&apos;s Disease (PD) show important distortions in speech, affecting fluency, prosody, articulation and phonation. Classically, measurements based on articulation gestures altering formant positions, as the Vocal Space Area (VSA) or the Formant Centralization Ratio (FCR) have been proposed to measure speech distortion, but these markers are based mainly on static positions of sustained vowels. The present study introduces a measurement based on the mutual information distance among probability density functions of kinematic correlates derived from formant dynamics. An absolute kinematic velocity associated to the position of the jaw and tongue articulation gestures is estimated and modeled statistically. The distribution of this feature may differentiate PD patients from normative speakers during sustained vowel emission. The study is based on a limited database of 53 male PD patients, contrasted to a very selected and stable set of eight normative speakers. In this sense, distances based on Kullback-Leibler divergence seem to be sensitive to PD articulation instability. Correlation studies show statistically relevant relationship between information contents based on articulation instability to certain motor and nonmotor clinical scores, such as freezing of gait, or sleep disorders. Remarkably, one of the statistically relevant correlations point out to the time interval passed since the first diagnostic. These results stress the need of defining scoring scales specifically designed for speech disability estimation and monitoring methodologies in degenerative diseases of neuromotor origin.

Název v anglickém jazyce

Vowel Articulation Dynamic Stability Related to Parkinson's Disease Rating Features: Male Dataset

Popis výsledku anglicky

Neurodegenerative pathologies as Parkinson&apos;s Disease (PD) show important distortions in speech, affecting fluency, prosody, articulation and phonation. Classically, measurements based on articulation gestures altering formant positions, as the Vocal Space Area (VSA) or the Formant Centralization Ratio (FCR) have been proposed to measure speech distortion, but these markers are based mainly on static positions of sustained vowels. The present study introduces a measurement based on the mutual information distance among probability density functions of kinematic correlates derived from formant dynamics. An absolute kinematic velocity associated to the position of the jaw and tongue articulation gestures is estimated and modeled statistically. The distribution of this feature may differentiate PD patients from normative speakers during sustained vowel emission. The study is based on a limited database of 53 male PD patients, contrasted to a very selected and stable set of eight normative speakers. In this sense, distances based on Kullback-Leibler divergence seem to be sensitive to PD articulation instability. Correlation studies show statistically relevant relationship between information contents based on articulation instability to certain motor and nonmotor clinical scores, such as freezing of gait, or sleep disorders. Remarkably, one of the statistically relevant correlations point out to the time interval passed since the first diagnostic. These results stress the need of defining scoring scales specifically designed for speech disability estimation and monitoring methodologies in degenerative diseases of neuromotor origin.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30200 - Clinical medicine

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Neural Systems

ISSN

0129-0657

e-ISSN

—

Svazek periodika

29

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

SG - Singapurská republika

Počet stran výsledku

13

Strana od-do

1850037

Kód UT WoS článku

000459454300003

EID výsledku v databázi Scopus

2-s2.0-85055162866