Can Nutrition or Inflammation Moderate the Age-Cognition Association Among Older Adults?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F19%3A00071050" target="_blank" >RIV/00159816:_____/19:00071050 - isvavai.cz</a>

Výsledek na webu

<a href="https://academic.oup.com/psychsocgerontology/article/74/2/193/3800357" target="_blank" >https://academic.oup.com/psychsocgerontology/article/74/2/193/3800357</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/geronb/gbx054" target="_blank" >10.1093/geronb/gbx054</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Can Nutrition or Inflammation Moderate the Age-Cognition Association Among Older Adults?

Popis výsledku v původním jazyce

Objectives Previous research has shown that nutrition can influence cognitive abilities in older adults. We examined whether nutritional factors or inflammatory biomarkers moderate the age-cognition association. Method Analyses included 1,308 participants (age 60) from the National Health and Nutrition Examination Survey III. Macronutrients (% of calories from fat, protein, and carbohydrates), micronutrients/amino acids (blood serum values: Vitamins B12(,) C, D, E, folate, iron, homocysteine, and -carotene), and inflammatory biomarkers (serum C-reactive protein, plasma fibrinogen, and serum ferritin) were examined as moderators with cognition. Cognition was measured by six tasks: immediate and delayed story recall, immediate and delayed word memory, digit subtraction, and questions about place/orientation. Results Higher values of serum folate were significantly associated with better cognitive scores. Specifically, the interaction between age-cognition and folate indicated the associations of higher age and lower global cognition and lower immediate story recall were weaker in those with higher folate values (p&apos;s &lt; .05). A significant interaction between age and plasma fibrinogen indicated that the association between age and worse digit subtraction was stronger with values &gt;3.1 g/L. Discussion Folate and fibrinogen were significant moderators between age and cognition. Further research into the relationship between nutrition, inflammation, and cognitive aging is needed.

Název v anglickém jazyce

Can Nutrition or Inflammation Moderate the Age-Cognition Association Among Older Adults?

Popis výsledku anglicky

Objectives Previous research has shown that nutrition can influence cognitive abilities in older adults. We examined whether nutritional factors or inflammatory biomarkers moderate the age-cognition association. Method Analyses included 1,308 participants (age 60) from the National Health and Nutrition Examination Survey III. Macronutrients (% of calories from fat, protein, and carbohydrates), micronutrients/amino acids (blood serum values: Vitamins B12(,) C, D, E, folate, iron, homocysteine, and -carotene), and inflammatory biomarkers (serum C-reactive protein, plasma fibrinogen, and serum ferritin) were examined as moderators with cognition. Cognition was measured by six tasks: immediate and delayed story recall, immediate and delayed word memory, digit subtraction, and questions about place/orientation. Results Higher values of serum folate were significantly associated with better cognitive scores. Specifically, the interaction between age-cognition and folate indicated the associations of higher age and lower global cognition and lower immediate story recall were weaker in those with higher folate values (p&apos;s &lt; .05). A significant interaction between age and plasma fibrinogen indicated that the association between age and worse digit subtraction was stronger with values &gt;3.1 g/L. Discussion Folate and fibrinogen were significant moderators between age and cognition. Further research into the relationship between nutrition, inflammation, and cognitive aging is needed.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30227 - Geriatrics and gerontology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journals of Gerontology series B - Psychological Sciences and Social Sciences

ISSN

1079-5014

e-ISSN

—

Svazek periodika

74

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

193-201

Kód UT WoS článku

000462568900001

EID výsledku v databázi Scopus

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