Options for modeling the respiratory system: inserts, scaffolds and microfluidic chips

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F19%3A00071085" target="_blank" >RIV/00159816:_____/19:00071085 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/19:00108503

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1359644618304458" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1359644618304458</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.drudis.2019.03.006" target="_blank" >10.1016/j.drudis.2019.03.006</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Options for modeling the respiratory system: inserts, scaffolds and microfluidic chips

Popis výsledku v původním jazyce

The human respiratory system is continuously exposed to varying levels of hazardous substances ranging from environmental toxins to purposely administered drugs. If the noxious effects exceed the inherent regenerative capacity of the respiratory system, injured tissue undergoes complex remodeling that can significantly affect lung function and lead to various diseases. Advanced near-to-native in vitro lung models are required to understand the mechanisms involved in pulmonary damage and repair and to reliably test the toxicity of compounds to lung tissue. This review is an overview of the development of in vitro respiratory system models used for study of lung diseases. It includes discussion of using these models for environmental toxin assessment and pulmonary toxicity screening.

Název v anglickém jazyce

Options for modeling the respiratory system: inserts, scaffolds and microfluidic chips

Popis výsledku anglicky

The human respiratory system is continuously exposed to varying levels of hazardous substances ranging from environmental toxins to purposely administered drugs. If the noxious effects exceed the inherent regenerative capacity of the respiratory system, injured tissue undergoes complex remodeling that can significantly affect lung function and lead to various diseases. Advanced near-to-native in vitro lung models are required to understand the mechanisms involved in pulmonary damage and repair and to reliably test the toxicity of compounds to lung tissue. This review is an overview of the development of in vitro respiratory system models used for study of lung diseases. It includes discussion of using these models for environmental toxin assessment and pulmonary toxicity screening.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

<a href="/cs/project/NV16-31501A" target="_blank" >NV16-31501A: Tkáňové inženýrství epitelů: Buňky a protokoly pro regenerativní medicínu</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

DRUG DISCOVERY TODAY

ISSN

1359-6446

e-ISSN

—

Svazek periodika

24

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

12

Strana od-do

971-982

Kód UT WoS článku

000467511200007

EID výsledku v databázi Scopus

—