Using Lung Organoids to Investigate Epithelial Barrier Complexity and IL-17 Signaling During Respiratory Infection

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F19%3A00071092" target="_blank" >RIV/00159816:_____/19:00071092 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.frontiersin.org/articles/10.3389/fimmu.2019.00323/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fimmu.2019.00323/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fimmu.2019.00323" target="_blank" >10.3389/fimmu.2019.00323</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Using Lung Organoids to Investigate Epithelial Barrier Complexity and IL-17 Signaling During Respiratory Infection

Popis výsledku v původním jazyce

The respiratory system is the first point of contact with airborne microbial compounds. Consequently, lung mucosal immunity has been extensively studied to understand the mechanisms of host resistance to respiratory infections. The lungs exhibit highly active innate and adaptive mucosal immune mechanisms: they are infiltrated with a wide spectrum of immune cells in steady state and possess the capacity to recruit vast numbers of infiltrating cells upon infection or encounter with inflammatory stimuli. Despite the existence of such protective mechanisms, respiratory tract infections (RTIs) with epidemic and pandemic potential are one of the most common causes of morbidity and mortality worldwide. In recent years, studies using new lung culture systems, such as air liquid interface (ALI), spheroids, tissue explants and advances in DNA sequencing technology have helped identify that the upper and lower respiratory tracts represent distinct biomes in terms of their commensal microorganism colonization, immune barriers and host defense mechanisms (1-3). Most lower respiratory tract infections (LRTIs) cause bronchitis, bronchiolitis and pneumonia as a result of Streptococcus pneumonia or Haemophilus Influenzae infection. In children, respiratory viruses are responsible for an enormous amount of serious LRTIs (4, 5). In addition, most upper respiratory tract infections are of viral etiology (6). Fungal infections of the lower respiratory tract are also typically caused by pathogenic dimorphic fungi (7). In addition, opportunistic fungi as Aspergillus fumigatus commonly cause pneumonia. There is an extraordinary need to better understand human respiratory tract infections, as LRTI represent one of the ten most common causes of death in the world (8).

Název v anglickém jazyce

Using Lung Organoids to Investigate Epithelial Barrier Complexity and IL-17 Signaling During Respiratory Infection

Popis výsledku anglicky

The respiratory system is the first point of contact with airborne microbial compounds. Consequently, lung mucosal immunity has been extensively studied to understand the mechanisms of host resistance to respiratory infections. The lungs exhibit highly active innate and adaptive mucosal immune mechanisms: they are infiltrated with a wide spectrum of immune cells in steady state and possess the capacity to recruit vast numbers of infiltrating cells upon infection or encounter with inflammatory stimuli. Despite the existence of such protective mechanisms, respiratory tract infections (RTIs) with epidemic and pandemic potential are one of the most common causes of morbidity and mortality worldwide. In recent years, studies using new lung culture systems, such as air liquid interface (ALI), spheroids, tissue explants and advances in DNA sequencing technology have helped identify that the upper and lower respiratory tracts represent distinct biomes in terms of their commensal microorganism colonization, immune barriers and host defense mechanisms (1-3). Most lower respiratory tract infections (LRTIs) cause bronchitis, bronchiolitis and pneumonia as a result of Streptococcus pneumonia or Haemophilus Influenzae infection. In children, respiratory viruses are responsible for an enormous amount of serious LRTIs (4, 5). In addition, most upper respiratory tract infections are of viral etiology (6). Fungal infections of the lower respiratory tract are also typically caused by pathogenic dimorphic fungi (7). In addition, opportunistic fungi as Aspergillus fumigatus commonly cause pneumonia. There is an extraordinary need to better understand human respiratory tract infections, as LRTI represent one of the ten most common causes of death in the world (8).

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30102 - Immunology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Frontiers in Immunology

ISSN

1664-3224

e-ISSN

—

Svazek periodika

10

Číslo periodika v rámci svazku

February

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

6

Strana od-do

—

Kód UT WoS článku

000459851000001

EID výsledku v databázi Scopus

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