Hyperglycemia potentiates the effect of ionic calcium in photoreceptor ellipsoid zone disruption in diabetic retinopathy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F19%3A00071341" target="_blank" >RIV/00159816:_____/19:00071341 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/19:00111747

Výsledek na webu

<a href="https://link.springer.com/article/10.1007%2Fs10792-018-01063-8" target="_blank" >https://link.springer.com/article/10.1007%2Fs10792-018-01063-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10792-018-01063-8" target="_blank" >10.1007/s10792-018-01063-8</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Hyperglycemia potentiates the effect of ionic calcium in photoreceptor ellipsoid zone disruption in diabetic retinopathy

Popis výsledku v původním jazyce

PurposeTo study the association of serum ionic calcium and glycated hemoglobin (HbA1c) with retinal photoreceptor ellipsoid zone (EZ) disruption in diabetic retinopathy (DR). MethodsThis is a tertiary care center-based observational cross-sectional study. Sixty-three consecutive cases, divided into 21 cases each with no diabetic retinopathy, non-proliferative diabetic retinopathy and proliferative diabetic retinopathy were included. Twenty-one healthy controls were also included. Ellipsoid zone disruption was assessed using spectral-domain optical coherence tomography. Serum ionic calcium and HbA1c were measured using standard protocol. Patient data from cases were divided into two groups according to their HbA1c levels: group 1 (HbA1c&lt;7, n=26) and group 2 (HbA1c&gt;7, n=37). Data were analyzed statistically.ResultsMean ionic calcium levels in group 1 and group 2 were 1.1310.073 mmol/dL and 1.170 +/- 0.070 mmol/dL, respectively. In group 1, 11 out of 26 had EZ disruption (42.3%). Similarly, in group 2, 29 out of 37 had EZ disruption (78.4%). On logistic regression analysis, as compared to group 1, ellipsoid zone disruption was found to be positively associated with serum ionic calcium (p=0.01) in group 2 cases.Conclusionp id=ParIncreased levels of serum ionic calcium are associated with increased EZ disruption in patients with HbA1c&gt;7 in DR.

Název v anglickém jazyce

Hyperglycemia potentiates the effect of ionic calcium in photoreceptor ellipsoid zone disruption in diabetic retinopathy

Popis výsledku anglicky

PurposeTo study the association of serum ionic calcium and glycated hemoglobin (HbA1c) with retinal photoreceptor ellipsoid zone (EZ) disruption in diabetic retinopathy (DR). MethodsThis is a tertiary care center-based observational cross-sectional study. Sixty-three consecutive cases, divided into 21 cases each with no diabetic retinopathy, non-proliferative diabetic retinopathy and proliferative diabetic retinopathy were included. Twenty-one healthy controls were also included. Ellipsoid zone disruption was assessed using spectral-domain optical coherence tomography. Serum ionic calcium and HbA1c were measured using standard protocol. Patient data from cases were divided into two groups according to their HbA1c levels: group 1 (HbA1c&lt;7, n=26) and group 2 (HbA1c&gt;7, n=37). Data were analyzed statistically.ResultsMean ionic calcium levels in group 1 and group 2 were 1.1310.073 mmol/dL and 1.170 +/- 0.070 mmol/dL, respectively. In group 1, 11 out of 26 had EZ disruption (42.3%). Similarly, in group 2, 29 out of 37 had EZ disruption (78.4%). On logistic regression analysis, as compared to group 1, ellipsoid zone disruption was found to be positively associated with serum ionic calcium (p=0.01) in group 2 cases.Conclusionp id=ParIncreased levels of serum ionic calcium are associated with increased EZ disruption in patients with HbA1c&gt;7 in DR.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30207 - Ophthalmology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

INTERNATIONAL OPHTHALMOLOGY

ISSN

0165-5701

e-ISSN

—

Svazek periodika

39

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

2237-2243

Kód UT WoS článku

000491942400011

EID výsledku v databázi Scopus

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