Roles of IL-2 in bridging adaptive and innate immunity, and as a tool for cellular immunotherapy
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F20%3A00072912" target="_blank" >RIV/00159816:_____/20:00072912 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00023736:_____/20:00013017
Výsledek na webu
<a href="https://jlb.onlinelibrary.wiley.com/doi/full/10.1002/JLB.5MIR0420-055R" target="_blank" >https://jlb.onlinelibrary.wiley.com/doi/full/10.1002/JLB.5MIR0420-055R</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/JLB.5MIR0420-055R" target="_blank" >10.1002/JLB.5MIR0420-055R</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Roles of IL-2 in bridging adaptive and innate immunity, and as a tool for cellular immunotherapy
Popis výsledku v původním jazyce
IL-2 was initially characterized as a T cell growth factor in the 1970s, and has been studied intensively ever since. Decades of research have revealed multiple and diverse roles for this potent cytokine, indicating a unique linking role between adaptive and innate arms of the immune system. Here, we review the literature showing that IL-2 is expressed in a plethora of cell types across the immune system, where it has indispensable functions in orchestrating cellular interactions and shaping the nature and magnitude of immune responses. Emerging from the basic research that has revealed the molecular mechanisms and the complexity of the biologic actions of IL-2, several immunotherapeutic approaches have now focused on manipulating the levels of this cytokine in patients. These strategies range from inhibition of IL-2 to achieve immunosuppression, to the application of IL-2 as a vaccine adjuvant and in cancer therapies. This review will systematically summarize the major findings in the field and identify key areas requiring further research in order to realize the potential of IL-2 in the treatment of human diseases.
Název v anglickém jazyce
Roles of IL-2 in bridging adaptive and innate immunity, and as a tool for cellular immunotherapy
Popis výsledku anglicky
IL-2 was initially characterized as a T cell growth factor in the 1970s, and has been studied intensively ever since. Decades of research have revealed multiple and diverse roles for this potent cytokine, indicating a unique linking role between adaptive and innate arms of the immune system. Here, we review the literature showing that IL-2 is expressed in a plethora of cell types across the immune system, where it has indispensable functions in orchestrating cellular interactions and shaping the nature and magnitude of immune responses. Emerging from the basic research that has revealed the molecular mechanisms and the complexity of the biologic actions of IL-2, several immunotherapeutic approaches have now focused on manipulating the levels of this cytokine in patients. These strategies range from inhibition of IL-2 to achieve immunosuppression, to the application of IL-2 as a vaccine adjuvant and in cancer therapies. This review will systematically summarize the major findings in the field and identify key areas requiring further research in order to realize the potential of IL-2 in the treatment of human diseases.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10601 - Cell biology
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2020
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of leukocyte biology
ISSN
0741-5400
e-ISSN
—
Svazek periodika
108
Číslo periodika v rámci svazku
1
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
11
Strana od-do
427-437
Kód UT WoS článku
000536718100001
EID výsledku v databázi Scopus
—