Neuropsychiatric symptoms as early manifestation of Alzheimer's disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F20%3A00072958" target="_blank" >RIV/00159816:_____/20:00072958 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.csnn.eu/en/journals/czech-and-slovak-neurology-and-neurosurgery/2020-1-4/neuropsychiatric-symp-toms-as-early-manifestation-of-alzheimer-s-dis-ease-121153?hl=cs" target="_blank" >https://www.csnn.eu/en/journals/czech-and-slovak-neurology-and-neurosurgery/2020-1-4/neuropsychiatric-symp-toms-as-early-manifestation-of-alzheimer-s-dis-ease-121153?hl=cs</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14735/amcsnn202064" target="_blank" >10.14735/amcsnn202064</a>

Jazyk výsledku

čeština

Název v původním jazyce

Neuropsychiatric symptoms as early manifestation of Alzheimer's disease

Popis výsledku v původním jazyce

Aim: Neuropsychiatric symptoms (NPS) are a heterogeneous group of changes in personality and behavior that can be observed already in early stages of Alzheimer&apos;s disease (AD). Mild behavioral impairment (MBI) is a newly developed diagnostic category describing persistent changes in personality and behavior starting later in life. Based on these criteria, a new measure, the Mild Behavioral Impairment Checklist (MBI-C) has been developed, aimed at detecting NPS in early stages of AD. The aim of this study is to present the newly adapted Czech version of the MBI-C and to explore the presence of NPS in a pilot group of patients. Patients and methods: The original MBI-C has been adapted to Czech and administered to close informants of 188 patients. The patients were divided according to the results of a complex neuropsychological, neurological examination and brain imaging into 3 groups: cognitively normal (N = 69), amnestic mild cognitive impairment (aMCI; N = 87) and dementia due to AD (N = 32). Results: Patients with aMCI expressed in the MBI-C significantly more severe score compared to cognitively normal subjects and less severe compared to dementia patients. The differences were observed mainly in affective, motivation and impulse control domains. Conclusion: The Czech version of the MBI-C detects the presence of NPS even before the onset of dementia syndrome and is useful in clinical practice.

Název v anglickém jazyce

Neuropsychiatric symptoms as early manifestation of Alzheimer's disease

Popis výsledku anglicky

Aim: Neuropsychiatric symptoms (NPS) are a heterogeneous group of changes in personality and behavior that can be observed already in early stages of Alzheimer&apos;s disease (AD). Mild behavioral impairment (MBI) is a newly developed diagnostic category describing persistent changes in personality and behavior starting later in life. Based on these criteria, a new measure, the Mild Behavioral Impairment Checklist (MBI-C) has been developed, aimed at detecting NPS in early stages of AD. The aim of this study is to present the newly adapted Czech version of the MBI-C and to explore the presence of NPS in a pilot group of patients. Patients and methods: The original MBI-C has been adapted to Czech and administered to close informants of 188 patients. The patients were divided according to the results of a complex neuropsychological, neurological examination and brain imaging into 3 groups: cognitively normal (N = 69), amnestic mild cognitive impairment (aMCI; N = 87) and dementia due to AD (N = 32). Results: Patients with aMCI expressed in the MBI-C significantly more severe score compared to cognitively normal subjects and less severe compared to dementia patients. The differences were observed mainly in affective, motivation and impulse control domains. Conclusion: The Czech version of the MBI-C detects the presence of NPS even before the onset of dementia syndrome and is useful in clinical practice.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/LQ1605" target="_blank" >LQ1605: Translační medicína</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Česká a slovenská neurologie a neurochirurgie

ISSN

1210-7859

e-ISSN

—

Svazek periodika

83

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

9

Strana od-do

64-72

Kód UT WoS článku

000514084800009

EID výsledku v databázi Scopus

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