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Spatial Pattern Separation in Early Alzheimer's Disease

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F20%3A00072985" target="_blank" >RIV/00159816:_____/20:00072985 - isvavai.cz</a>

  • Výsledek na webu

    <a href="https://content.iospress.com/articles/journal-of-alzheimers-disease/jad200093" target="_blank" >https://content.iospress.com/articles/journal-of-alzheimers-disease/jad200093</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3233/JAD-200093" target="_blank" >10.3233/JAD-200093</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Spatial Pattern Separation in Early Alzheimer's Disease

  • Popis výsledku v původním jazyce

    Background: The hippocampus, entorhinal cortex, and basal forebrain are among the first brain structures affected by Alzheimer&apos;s disease (AD). They play an essential role in spatial pattern separation, a process critical for accurate encoding of similar spatial information. Objective: Our aimwas to examine spatial pattern separation and its association with volumetric changes of the hippocampus, entorhinal cortex, and basal forebrain nuclei projecting to the hippocampus (the medial septal nuclei and vertical limb of the diagonal band of Broca - Ch1-2 nuclei) in the biomarker-defined early clinical stages of AD. Methods: A total of 98 older adults were recruited from the Czech Brain Aging Study cohort. The participants with amnestic mild cognitive impairment (aMCI) due to AD (n = 44), mild AD dementia (n = 31), and cognitively normal older adults (CN; n = 23) underwent spatial pattern separation testing, comprehensive cognitive assessment, and MRI brain volumetry. Results: Spatial pattern separation accuracywas lower in the early clinical stages ofADcompared to theCNgroup (p &lt; 0.001) and decreased with disease severity (CN &gt; aMCI due to AD&gt; AD dementia). Controlling for general memory and cognitive performance, demographic characteristics and psychological factors did not change the results. Hippocampal and Ch1-2 volumes were directly associated with spatial pattern separation performance while the entorhinal cortex operated on pattern separation indirectly through the hippocampus. Conclusion: Smaller volumes of the hippocampus, entorhinal cortex, and basal forebrain Ch1-2 nuclei are linked to spatial pattern separation impairment in biomarker-defined early clinical AD and may contribute to AD-related spatial memory deficits.

  • Název v anglickém jazyce

    Spatial Pattern Separation in Early Alzheimer's Disease

  • Popis výsledku anglicky

    Background: The hippocampus, entorhinal cortex, and basal forebrain are among the first brain structures affected by Alzheimer&apos;s disease (AD). They play an essential role in spatial pattern separation, a process critical for accurate encoding of similar spatial information. Objective: Our aimwas to examine spatial pattern separation and its association with volumetric changes of the hippocampus, entorhinal cortex, and basal forebrain nuclei projecting to the hippocampus (the medial septal nuclei and vertical limb of the diagonal band of Broca - Ch1-2 nuclei) in the biomarker-defined early clinical stages of AD. Methods: A total of 98 older adults were recruited from the Czech Brain Aging Study cohort. The participants with amnestic mild cognitive impairment (aMCI) due to AD (n = 44), mild AD dementia (n = 31), and cognitively normal older adults (CN; n = 23) underwent spatial pattern separation testing, comprehensive cognitive assessment, and MRI brain volumetry. Results: Spatial pattern separation accuracywas lower in the early clinical stages ofADcompared to theCNgroup (p &lt; 0.001) and decreased with disease severity (CN &gt; aMCI due to AD&gt; AD dementia). Controlling for general memory and cognitive performance, demographic characteristics and psychological factors did not change the results. Hippocampal and Ch1-2 volumes were directly associated with spatial pattern separation performance while the entorhinal cortex operated on pattern separation indirectly through the hippocampus. Conclusion: Smaller volumes of the hippocampus, entorhinal cortex, and basal forebrain Ch1-2 nuclei are linked to spatial pattern separation impairment in biomarker-defined early clinical AD and may contribute to AD-related spatial memory deficits.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    30103 - Neurosciences (including psychophysiology)

Návaznosti výsledku

  • Projekt

    <a href="/cs/project/LQ1605" target="_blank" >LQ1605: Translační medicína</a><br>

  • Návaznosti

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Ostatní

  • Rok uplatnění

    2020

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Journal of Alzheimers Disease

  • ISSN

    1387-2877

  • e-ISSN

  • Svazek periodika

    76

  • Číslo periodika v rámci svazku

    1

  • Stát vydavatele periodika

    NL - Nizozemsko

  • Počet stran výsledku

    18

  • Strana od-do

    121-138

  • Kód UT WoS článku

    000545337600013

  • EID výsledku v databázi Scopus