Maternal Perinatal Nutrition and Offspring Programming

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F20%3A00073491" target="_blank" >RIV/00159816:_____/20:00073491 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/B9780128045725000161" target="_blank" >https://www.sciencedirect.com/science/article/pii/B9780128045725000161</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/B978-0-12-804572-5.00016-1" target="_blank" >10.1016/B978-0-12-804572-5.00016-1</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Maternal Perinatal Nutrition and Offspring Programming

Popis výsledku v původním jazyce

Maternal nutrition during pregnancy, and other perinatal periods, programs offspring physiology and metabolism, as well as the risk of suffering metabolic diseases during adulthood. During pregnancy, there is a double interaction of nutritional intake and genetic background due to the maternal feeding and genes, and fetal genetic information and in utero nutrient availability. The main molecular mechanism implicated in developmental programming appears to be epigenetics, which regulate gene expression patterns during embryo and postnatal stages in a cellular- and tissue-specific manner, affecting metabolic and physiologic-related key genes. Epigenetic profiles are nutritionally modulated, and also the expression patterns of genes related to nutrient metabolism can be epigenetic driven. Therefore, there appears a novel scientific perspective involving nutriepigenetic and nutriepigenomic regulation, which has to be integrated into the traditional nutrigenetic and nutrigenomic lines of sight. Interestingly, maternal programming may predispose the transcriptomic patterns during different lifetime periods and appear to be also transmissible across successive generations. Although human studies of developmental programming are recent and mainly observational, there is evidence of epigenetically driven programming due to different macro- and micronutrient distribution as well as by total caloric intake. However, although omics-based human approaches have importantly increased the knowledge for future nutrition-based epigenetic regulation, ethical and practical considerations lead to animal approaches as the most useful mechanistic research tool. There is still needed a deeper understanding of the nutritionally driven epigenetic reactions in utero that may lead to apply an effective personalized maternal nutrition during pregnancy.

Název v anglickém jazyce

Maternal Perinatal Nutrition and Offspring Programming

Popis výsledku anglicky

Maternal nutrition during pregnancy, and other perinatal periods, programs offspring physiology and metabolism, as well as the risk of suffering metabolic diseases during adulthood. During pregnancy, there is a double interaction of nutritional intake and genetic background due to the maternal feeding and genes, and fetal genetic information and in utero nutrient availability. The main molecular mechanism implicated in developmental programming appears to be epigenetics, which regulate gene expression patterns during embryo and postnatal stages in a cellular- and tissue-specific manner, affecting metabolic and physiologic-related key genes. Epigenetic profiles are nutritionally modulated, and also the expression patterns of genes related to nutrient metabolism can be epigenetic driven. Therefore, there appears a novel scientific perspective involving nutriepigenetic and nutriepigenomic regulation, which has to be integrated into the traditional nutrigenetic and nutrigenomic lines of sight. Interestingly, maternal programming may predispose the transcriptomic patterns during different lifetime periods and appear to be also transmissible across successive generations. Although human studies of developmental programming are recent and mainly observational, there is evidence of epigenetically driven programming due to different macro- and micronutrient distribution as well as by total caloric intake. However, although omics-based human approaches have importantly increased the knowledge for future nutrition-based epigenetic regulation, ethical and practical considerations lead to animal approaches as the most useful mechanistic research tool. There is still needed a deeper understanding of the nutritionally driven epigenetic reactions in utero that may lead to apply an effective personalized maternal nutrition during pregnancy.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

30308 - Nutrition, Dietetics

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Principles of Nutrigenetics and Nutrigenomics

ISBN

978-0-12-804572-5

Počet stran výsledku

7

Strana od-do

1-7

Počet stran knihy

586

Název nakladatele

Academic Press

Místo vydání

London

Kód UT WoS kapitoly

—