Non-coding RNAs and Cardiac Arrhythmias

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F20%3A00074077" target="_blank" >RIV/00159816:_____/20:00074077 - isvavai.cz</a>

Výsledek na webu

<a href="https://link.springer.com/chapter/10.1007%2F978-981-15-1671-9_17" target="_blank" >https://link.springer.com/chapter/10.1007%2F978-981-15-1671-9_17</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-981-15-1671-9_17" target="_blank" >10.1007/978-981-15-1671-9_17</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Non-coding RNAs and Cardiac Arrhythmias

Popis výsledku v původním jazyce

Cardiac arrhythmias represent wide and heterogenic group of disturbances in the cardiac rhythm. Pathophysiology of individual arrhythmias is highly complex and dysfunction in ion channels/currents involved in generation or spreading of action potential is usually documented. Non-coding RNAs (ncRNAs) represent highly variable group of molecules regulating the heart expression program, including regulation of the expression of individual ion channels and intercellular connection proteins, e.g. connexins. Within this chapter, we will describe basic electrophysiological properties of the myocardium. We will focus on action potential generation and spreading in pacemaker and non-pacemaker cells, including description of individual ion channels (natrium, potassium and calcium) and their ncRNA-mediated regulation. Most of the studies have so far focused on microRNAs, thus, their regulatory function will be described into greater detail. Clinical consequences of altered ncRNA regulatory function will also be described together with potential future directions of the research in the field.

Název v anglickém jazyce

Non-coding RNAs and Cardiac Arrhythmias

Popis výsledku anglicky

Cardiac arrhythmias represent wide and heterogenic group of disturbances in the cardiac rhythm. Pathophysiology of individual arrhythmias is highly complex and dysfunction in ion channels/currents involved in generation or spreading of action potential is usually documented. Non-coding RNAs (ncRNAs) represent highly variable group of molecules regulating the heart expression program, including regulation of the expression of individual ion channels and intercellular connection proteins, e.g. connexins. Within this chapter, we will describe basic electrophysiological properties of the myocardium. We will focus on action potential generation and spreading in pacemaker and non-pacemaker cells, including description of individual ion channels (natrium, potassium and calcium) and their ncRNA-mediated regulation. Most of the studies have so far focused on microRNAs, thus, their regulatory function will be described into greater detail. Clinical consequences of altered ncRNA regulatory function will also be described together with potential future directions of the research in the field.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

30200 - Clinical medicine

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Non-coding RNAs in Cardiovascular Diseases

ISBN

978-981-15-1671-9

Počet stran výsledku

14

Strana od-do

1-14

Počet stran knihy

426

Název nakladatele

Springer

Místo vydání

Singapore

Kód UT WoS kapitoly

—