PHAGOCYTOSIS-INFLAMMATION CROSSTALK IN SEPSIS: NEW AVENUES FOR THERAPEUTIC INTERVENTION

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F20%3A00074099" target="_blank" >RIV/00159816:_____/20:00074099 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/20:00118327 RIV/00023736:_____/20:00013135

Výsledek na webu

<a href="https://journals.lww.com/shockjournal/Fulltext/2020/11000/Phagocytosis_Inflammation_Crosstalk_in_Sepsis__New.4.aspx" target="_blank" >https://journals.lww.com/shockjournal/Fulltext/2020/11000/Phagocytosis_Inflammation_Crosstalk_in_Sepsis__New.4.aspx</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/SHK.0000000000001541" target="_blank" >10.1097/SHK.0000000000001541</a>

Jazyk výsledku

angličtina

Název v původním jazyce

PHAGOCYTOSIS-INFLAMMATION CROSSTALK IN SEPSIS: NEW AVENUES FOR THERAPEUTIC INTERVENTION

Popis výsledku v původním jazyce

Phagocytosis is a complex process by which cells within most organ systems remove pathogens and cell debris. Phagocytosis is usually followed by inflammatory pathway activation, which promotes pathogen elimination and inhibits pathogen growth. Delayed pathogen elimination is the first step in sepsis development and a key factor in sepsis resolution. Phagocytosis thus has an important role during sepsis and likely contributes to all of its clinical stages. However, only a few studies have specifically explored and characterized phagocytic activity during sepsis. Here, we describe the phagocytic processes that occur as part of the immune response preceding sepsis onset and identify the elements of phagocytosis that might constitute a predictive marker of sepsis outcomes. First, we detail the key features of phagocytosis, including the main receptors and signaling hallmarks associated with different phagocytic processes. We then discuss how the initial events of phagosome formation and cytoskeletal remodeling might be associated with known sepsis features, such as a cytokine-driven hyperinflammatory response and immunosuppression. Finally, we highlight the unresolved mechanisms of sepsis development and progression and the need for cross-disciplinary approaches to link the clinical complexity of the disease with basic cellular and molecular mechanisms.

Název v anglickém jazyce

PHAGOCYTOSIS-INFLAMMATION CROSSTALK IN SEPSIS: NEW AVENUES FOR THERAPEUTIC INTERVENTION

Popis výsledku anglicky

Phagocytosis is a complex process by which cells within most organ systems remove pathogens and cell debris. Phagocytosis is usually followed by inflammatory pathway activation, which promotes pathogen elimination and inhibits pathogen growth. Delayed pathogen elimination is the first step in sepsis development and a key factor in sepsis resolution. Phagocytosis thus has an important role during sepsis and likely contributes to all of its clinical stages. However, only a few studies have specifically explored and characterized phagocytic activity during sepsis. Here, we describe the phagocytic processes that occur as part of the immune response preceding sepsis onset and identify the elements of phagocytosis that might constitute a predictive marker of sepsis outcomes. First, we detail the key features of phagocytosis, including the main receptors and signaling hallmarks associated with different phagocytic processes. We then discuss how the initial events of phagosome formation and cytoskeletal remodeling might be associated with known sepsis features, such as a cytokine-driven hyperinflammatory response and immunosuppression. Finally, we highlight the unresolved mechanisms of sepsis development and progression and the need for cross-disciplinary approaches to link the clinical complexity of the disease with basic cellular and molecular mechanisms.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30221 - Critical care medicine and Emergency medicine

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Shock

ISSN

1073-2322

e-ISSN

—

Svazek periodika

54

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

606-614

Kód UT WoS článku

000619501000004

EID výsledku v databázi Scopus

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