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The molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in the Czech Republic

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00074440" target="_blank" >RIV/00159816:_____/21:00074440 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/00669806:_____/21:10416906 RIV/00216208:11120/21:43920725 RIV/00216208:11130/21:10416906 RIV/00216208:11140/21:10416906 a 6 dalších

  • Výsledek na webu

    <a href="https://academic.oup.com/jac/article-abstract/76/1/55/5942696?redirectedFrom=fulltext" target="_blank" >https://academic.oup.com/jac/article-abstract/76/1/55/5942696?redirectedFrom=fulltext</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1093/jac/dkaa404" target="_blank" >10.1093/jac/dkaa404</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    The molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in the Czech Republic

  • Popis výsledku v původním jazyce

    Objectives: To gain data on the current molecular epidemiology and resistance of MRSA in the Czech Republic. Methods: Between September 2017 and January 2018, a total of 441 single-patient MRSA isolates were collected from 11 Czech hospitals and analysed by spa typing, SCCmec typing, antibiotic susceptibility testing, detection of the PVL toxin and the arcA gene. Results: Of all MRSA isolates, 81.41% (n = 359) belonged to the CC5-MRSA clone represented by the spa types t003 (n = 136), t586 (n = 92), t014 (n = 81), t002 (n = 20) and other spa types (n = 30); a majority of the CC5 isolates (n = 348, 96.94%) carried SCCmec type II. The occurrence of CC5-MRSA was more Likely in older inpatients and associated with a healthcare origin (P&lt; 0.001). The CC5-MRSA isolates were resistant to more antimicrobial drugs compared with the other MRSAs (P&lt; 0.001). Interestingly, t586 was detected in blood samples more often than the other spa types and, contrary to other spa types belonging to CC5-MRSA, t586 was not associated with patients of advanced age. Other frequently found Lineages were CC8 (n = 17), CC398 (n = 11) and CC59 (n = 10). The presence of the PVL was detected in 8.62% (n = 38) of the MRSA isolates. Conclusions: The healthcare-associated CC5-MRSA-II Lineage (t003, t586, t014) was found to be predominant in the Czech Republic. t586 is a newly emerging spa type in the Czech Republic, yet reported rarely in other countries. Our observations stress the need for MRSA surveillance in the Czech Republic in order to monitor changes in MRSA epidemiology.

  • Název v anglickém jazyce

    The molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in the Czech Republic

  • Popis výsledku anglicky

    Objectives: To gain data on the current molecular epidemiology and resistance of MRSA in the Czech Republic. Methods: Between September 2017 and January 2018, a total of 441 single-patient MRSA isolates were collected from 11 Czech hospitals and analysed by spa typing, SCCmec typing, antibiotic susceptibility testing, detection of the PVL toxin and the arcA gene. Results: Of all MRSA isolates, 81.41% (n = 359) belonged to the CC5-MRSA clone represented by the spa types t003 (n = 136), t586 (n = 92), t014 (n = 81), t002 (n = 20) and other spa types (n = 30); a majority of the CC5 isolates (n = 348, 96.94%) carried SCCmec type II. The occurrence of CC5-MRSA was more Likely in older inpatients and associated with a healthcare origin (P&lt; 0.001). The CC5-MRSA isolates were resistant to more antimicrobial drugs compared with the other MRSAs (P&lt; 0.001). Interestingly, t586 was detected in blood samples more often than the other spa types and, contrary to other spa types belonging to CC5-MRSA, t586 was not associated with patients of advanced age. Other frequently found Lineages were CC8 (n = 17), CC398 (n = 11) and CC59 (n = 10). The presence of the PVL was detected in 8.62% (n = 38) of the MRSA isolates. Conclusions: The healthcare-associated CC5-MRSA-II Lineage (t003, t586, t014) was found to be predominant in the Czech Republic. t586 is a newly emerging spa type in the Czech Republic, yet reported rarely in other countries. Our observations stress the need for MRSA surveillance in the Czech Republic in order to monitor changes in MRSA epidemiology.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    10606 - Microbiology

Návaznosti výsledku

  • Projekt

    <a href="/cs/project/NV17-30460A" target="_blank" >NV17-30460A: Molekulární charakterizace mechanismů adaptivní rezistence a tolerance k antibiotikům u kmenů Staphylococcus aureus způsobujících chronické infekce</a><br>

  • Návaznosti

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Ostatní

  • Rok uplatnění

    2021

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Journal of antimicrobial chemotherapy

  • ISSN

    0305-7453

  • e-ISSN

  • Svazek periodika

    76

  • Číslo periodika v rámci svazku

    1

  • Stát vydavatele periodika

    GB - Spojené království Velké Británie a Severního Irska

  • Počet stran výsledku

    10

  • Strana od-do

    55-64

  • Kód UT WoS článku

    000620811500006

  • EID výsledku v databázi Scopus

    2-s2.0-85098466887