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Granulation tissue enriched by aspirin and omega-3 fatty acids in healing experimental periodontal lesion

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00074458" target="_blank" >RIV/00159816:_____/21:00074458 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/00027162:_____/21:N0000083 RIV/00216224:14110/21:00120585 RIV/65269705:_____/21:00074458

  • Výsledek na webu

    <a href="https://biomed.papers.upol.cz/artkey/bio-202102-0018_granulation-tissue-enriched-by-aspirin-and-omega-3-fatty-acids-in-healing-experimental-periodontal-lesion.php" target="_blank" >https://biomed.papers.upol.cz/artkey/bio-202102-0018_granulation-tissue-enriched-by-aspirin-and-omega-3-fatty-acids-in-healing-experimental-periodontal-lesion.php</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.5507/bp.2020.003" target="_blank" >10.5507/bp.2020.003</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Granulation tissue enriched by aspirin and omega-3 fatty acids in healing experimental periodontal lesion

  • Popis výsledku v původním jazyce

    Aims. Granulation tissue (GT) and specialized pro-resolving mediators such as lipoxins and resolvins are key elements in the successful resolution of periodontitis. Aspirin-triggered lipoxins and resolvins are even more powerful than their natural analogues. Their biosynthesis can be accelerated by omega-3 fatty acids. The aim of this study was to evaluate the use of GT enriched by aspirin and omega-3 fatty acids during the surgical treatment of periodontitis in an experimental animal model (rabbit). Methods. In each of 24 rabbits, two experimental periodontal defects were created. In total, 47 defects were treated with open-flap debridement and one of three procedures: (1) GT extracted and soaked with aspirin and omega-3 fatty acids (ASA+OMEGA3 group); (2) GT soaked with saline (PLACEBO group); or (3) GT left untreated (CONTROL group). Then, the GT was replaced in situ. Primary evaluated criteria were the probing pocket depth (PPD) and the clinical attachment level (CAL). Necropsies were harvested 2, 6, and 12 weeks after surgery. The samples were used for histological and molecular biological assessment. Results. A trend of greater PPD and CAL in the ASA+OMEGA3 group was observed at 6 weeks. However, there was no significant difference between them. During the observation period, tissue levels of FGF-7, IL-1 beta and TIMP-1 showed a statistically significant decrease (P&lt;0.05). For the other variables, the ASA+OMEGA3 group was comparable with the PLACEBO and CONTROL groups. Conclusion. This experiment did not demonstrate the superiority of the proposed approach. However, the enriched granulation tissue did not impair healing outcomes.

  • Název v anglickém jazyce

    Granulation tissue enriched by aspirin and omega-3 fatty acids in healing experimental periodontal lesion

  • Popis výsledku anglicky

    Aims. Granulation tissue (GT) and specialized pro-resolving mediators such as lipoxins and resolvins are key elements in the successful resolution of periodontitis. Aspirin-triggered lipoxins and resolvins are even more powerful than their natural analogues. Their biosynthesis can be accelerated by omega-3 fatty acids. The aim of this study was to evaluate the use of GT enriched by aspirin and omega-3 fatty acids during the surgical treatment of periodontitis in an experimental animal model (rabbit). Methods. In each of 24 rabbits, two experimental periodontal defects were created. In total, 47 defects were treated with open-flap debridement and one of three procedures: (1) GT extracted and soaked with aspirin and omega-3 fatty acids (ASA+OMEGA3 group); (2) GT soaked with saline (PLACEBO group); or (3) GT left untreated (CONTROL group). Then, the GT was replaced in situ. Primary evaluated criteria were the probing pocket depth (PPD) and the clinical attachment level (CAL). Necropsies were harvested 2, 6, and 12 weeks after surgery. The samples were used for histological and molecular biological assessment. Results. A trend of greater PPD and CAL in the ASA+OMEGA3 group was observed at 6 weeks. However, there was no significant difference between them. During the observation period, tissue levels of FGF-7, IL-1 beta and TIMP-1 showed a statistically significant decrease (P&lt;0.05). For the other variables, the ASA+OMEGA3 group was comparable with the PLACEBO and CONTROL groups. Conclusion. This experiment did not demonstrate the superiority of the proposed approach. However, the enriched granulation tissue did not impair healing outcomes.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    30100 - Basic medicine

Návaznosti výsledku

  • Projekt

    <a href="/cs/project/NV16-28462A" target="_blank" >NV16-28462A: Terapie chronické parodontitidy pomocí resolvinů a lipoxinů</a><br>

  • Návaznosti

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Ostatní

  • Rok uplatnění

    2021

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Biomedical papers

  • ISSN

    1213-8118

  • e-ISSN

  • Svazek periodika

    165

  • Číslo periodika v rámci svazku

    2

  • Stát vydavatele periodika

    CZ - Česká republika

  • Počet stran výsledku

    8

  • Strana od-do

    216-223

  • Kód UT WoS článku

    000660244900018

  • EID výsledku v databázi Scopus

    2-s2.0-85107146038