Correlation between vitamin D serum levels and severity of diabetic retinopathy in patients with type 2 diabetes mellitus

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00074658" target="_blank" >RIV/00159816:_____/21:00074658 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/21:00124187

Výsledek na webu

<a href="https://www.tandfonline.com/doi/full/10.1080/16089677.2021.1903170" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/16089677.2021.1903170</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/16089677.2021.1903170" target="_blank" >10.1080/16089677.2021.1903170</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Correlation between vitamin D serum levels and severity of diabetic retinopathy in patients with type 2 diabetes mellitus

Popis výsledku v původním jazyce

Purpose: To study the correlation of serum vitamin D levels with quantitative (central subfield thickness [CST], cube average thickness [CAT]), cross-sectional (disorganisation of retinal inner layer [DRIL] and ellipsoid zone [EZ]) and topographic parameters (retinal pigment epithelium [RPE]) on spectral domain optical coherence tomography (SD-OCT) in diabetic retinopathy (DR), for the first time. Methods: Eighty-eight consecutive cases of type 2 diabetes mellitus with no retinopathy (No DR; n = 22); non-proliferative DR (NPDR; n = 22); proliferative DR (PDR; n = 22) and healthy controls (n = 22) were included, after sample size calculation. On SDOCT, physician-friendly grading systems were created for DRIL, EZ disruption and RPE alterations. Serum vitamin D was analysed using a standard protocol. Statistical analysis was done using Pearson correlation, Student&apos;s t-test, ANOVA, Newman-Keuls test, chi-square test and univariate ordinal logistic regression analysis. Results: Mean serum vitamin D levels (ng/ml) were: No DR = 23.36 +/- 2.00, NPDR = 17.88 +/- 1.86, PDR = 14.07 +/- 1.21, and controls = 25.11 +/- 1.59. Low vitamin D levels correlated significantly with severity of retinopathy, VA (r = 0.50), CST (r = 0.36), CAT (r = 0.41), DRIL (r = 0.35), EZ disruption (r =0.40) and RPE alterations (r=0.37), respectively (p &lt;0.01). Significantly low vitamin D levels were observed in subjects with DRIL present versus DRIL absent; EZ disruption, focal versus global versus intact; RPE alterations, focal versus global versus none, respectively (p &lt; 0.05). Conclusions: Low serum vitamin D levels correlate with the presence of DRIL, EZ disruption and RPE alterations and increased severity of DR.

Název v anglickém jazyce

Correlation between vitamin D serum levels and severity of diabetic retinopathy in patients with type 2 diabetes mellitus

Popis výsledku anglicky

Purpose: To study the correlation of serum vitamin D levels with quantitative (central subfield thickness [CST], cube average thickness [CAT]), cross-sectional (disorganisation of retinal inner layer [DRIL] and ellipsoid zone [EZ]) and topographic parameters (retinal pigment epithelium [RPE]) on spectral domain optical coherence tomography (SD-OCT) in diabetic retinopathy (DR), for the first time. Methods: Eighty-eight consecutive cases of type 2 diabetes mellitus with no retinopathy (No DR; n = 22); non-proliferative DR (NPDR; n = 22); proliferative DR (PDR; n = 22) and healthy controls (n = 22) were included, after sample size calculation. On SDOCT, physician-friendly grading systems were created for DRIL, EZ disruption and RPE alterations. Serum vitamin D was analysed using a standard protocol. Statistical analysis was done using Pearson correlation, Student&apos;s t-test, ANOVA, Newman-Keuls test, chi-square test and univariate ordinal logistic regression analysis. Results: Mean serum vitamin D levels (ng/ml) were: No DR = 23.36 +/- 2.00, NPDR = 17.88 +/- 1.86, PDR = 14.07 +/- 1.21, and controls = 25.11 +/- 1.59. Low vitamin D levels correlated significantly with severity of retinopathy, VA (r = 0.50), CST (r = 0.36), CAT (r = 0.41), DRIL (r = 0.35), EZ disruption (r =0.40) and RPE alterations (r=0.37), respectively (p &lt;0.01). Significantly low vitamin D levels were observed in subjects with DRIL present versus DRIL absent; EZ disruption, focal versus global versus intact; RPE alterations, focal versus global versus none, respectively (p &lt; 0.05). Conclusions: Low serum vitamin D levels correlate with the presence of DRIL, EZ disruption and RPE alterations and increased severity of DR.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Endocrinology, Metabolism and Diabetes of South Africa

ISSN

1608-9677

e-ISSN

—

Svazek periodika

26

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

82-88

Kód UT WoS článku

000694947100002

EID výsledku v databázi Scopus

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