Altered Spatiotemporal Dynamics of the Resting Brain in Mild Cognitive Impairment with Lewy Bodies

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00074915" target="_blank" >RIV/00159816:_____/21:00074915 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14740/21:00120175

Výsledek na webu

<a href="https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.28741" target="_blank" >https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.28741</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/mds.28741" target="_blank" >10.1002/mds.28741</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Altered Spatiotemporal Dynamics of the Resting Brain in Mild Cognitive Impairment with Lewy Bodies

Popis výsledku v původním jazyce

Background Electrophysiological markers of prodromal dementia with Lewy bodies were described in the spectral domain. The sub-second temporal resolution may provide additional information. Objective To evaluate electroencephalography (EEG) microstates in patients with mild cognitive impairment with Lewy bodies and to assess the association between their temporal dynamics and the spectral marker. Methods Temporal parameters of microstates were compared between 21 patients with mild cognitive impairment with Lewy bodies and 21 healthy controls. The dominant alpha frequency was correlated with microstate parameters. Results Microstates A-D showed higher occurrence in the patient group. Microstate B additionally revealed shorter mean duration and increased time coverage; its occurrence correlated with the dominant alpha frequency in the patient group. Conclusions Temporal dynamics of all EEG microstates were altered in medication-naive subjects with prodromal dementia with Lewy bodies. Longitudinal follow-up may reveal how EEG microstates reflect progression of brain function deficits and effects of treatment manipulations. (c) 2021 International Parkinson and Movement Disorder Society

Název v anglickém jazyce

Altered Spatiotemporal Dynamics of the Resting Brain in Mild Cognitive Impairment with Lewy Bodies

Popis výsledku anglicky

Background Electrophysiological markers of prodromal dementia with Lewy bodies were described in the spectral domain. The sub-second temporal resolution may provide additional information. Objective To evaluate electroencephalography (EEG) microstates in patients with mild cognitive impairment with Lewy bodies and to assess the association between their temporal dynamics and the spectral marker. Methods Temporal parameters of microstates were compared between 21 patients with mild cognitive impairment with Lewy bodies and 21 healthy controls. The dominant alpha frequency was correlated with microstate parameters. Results Microstates A-D showed higher occurrence in the patient group. Microstate B additionally revealed shorter mean duration and increased time coverage; its occurrence correlated with the dominant alpha frequency in the patient group. Conclusions Temporal dynamics of all EEG microstates were altered in medication-naive subjects with prodromal dementia with Lewy bodies. Longitudinal follow-up may reveal how EEG microstates reflect progression of brain function deficits and effects of treatment manipulations. (c) 2021 International Parkinson and Movement Disorder Society

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Movement disorders

ISSN

0885-3185

e-ISSN

—

Svazek periodika

36

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

2435-2440

Kód UT WoS článku

000680728300001

EID výsledku v databázi Scopus

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