Travel burden and clinical presentation of retinoblastoma: analysis of 1024 patients from 43 African countries and 518 patients from 40 European countries

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00075034" target="_blank" >RIV/00159816:_____/21:00075034 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/65269705:_____/21:00075034 RIV/00064203:_____/21:10415919 RIV/00216208:11130/21:10415919 RIV/00216224:14110/21:00124151

Výsledek na webu

<a href="https://bjo.bmj.com/content/105/10/1435" target="_blank" >https://bjo.bmj.com/content/105/10/1435</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1136/bjophthalmol-2020-316613" target="_blank" >10.1136/bjophthalmol-2020-316613</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Travel burden and clinical presentation of retinoblastoma: analysis of 1024 patients from 43 African countries and 518 patients from 40 European countries

Popis výsledku v původním jazyce

Background The travel distance from home to a treatment centre, which may impact the stage at diagnosis, has not been investigated for retinoblastoma, the most common childhood eye cancer. We aimed to investigate the travel burden and its impact on clinical presentation in a large sample of patients with retinoblastoma from Africa and Europe. Methods A cross-sectional analysis including 518 treatment-naive patients with retinoblastoma residing in 40 European countries and 1024 treatment-naive patients with retinoblastoma residing in 43 African countries. Results Capture rate was 42.2% of expected patients from Africa and 108.8% from Europe. African patients were older (95% CI -12.4 to -5.4, p&lt;0.001), had fewer cases of familial retinoblastoma (95% CI 2.0 to 5.3, p&lt;0.001) and presented with more advanced disease (95% CI 6.0 to 9.8, p&lt;0.001); 43.4% and 15.4% of Africans had extraocular retinoblastoma and distant metastasis at the time of diagnosis, respectively, compared to 2.9% and 1.0% of the Europeans. To reach a retinoblastoma centre, European patients travelled 421.8 km compared to Africans who travelled 185.7 km (p&lt;0.001). On regression analysis, lower-national income level, African residence and older age (p&lt;0.001), but not travel distance (p=0.19), were risk factors for advanced disease. Conclusions Fewer than half the expected number of patients with retinoblastoma presented to African referral centres in 2017, suggesting poor awareness or other barriers to access. Despite the relatively shorter distance travelled by African patients, they presented with later-stage disease. Health education about retinoblastoma is needed for carers and health workers in Africa in order to increase capture rate and promote early referral.

Název v anglickém jazyce

Travel burden and clinical presentation of retinoblastoma: analysis of 1024 patients from 43 African countries and 518 patients from 40 European countries

Popis výsledku anglicky

Background The travel distance from home to a treatment centre, which may impact the stage at diagnosis, has not been investigated for retinoblastoma, the most common childhood eye cancer. We aimed to investigate the travel burden and its impact on clinical presentation in a large sample of patients with retinoblastoma from Africa and Europe. Methods A cross-sectional analysis including 518 treatment-naive patients with retinoblastoma residing in 40 European countries and 1024 treatment-naive patients with retinoblastoma residing in 43 African countries. Results Capture rate was 42.2% of expected patients from Africa and 108.8% from Europe. African patients were older (95% CI -12.4 to -5.4, p&lt;0.001), had fewer cases of familial retinoblastoma (95% CI 2.0 to 5.3, p&lt;0.001) and presented with more advanced disease (95% CI 6.0 to 9.8, p&lt;0.001); 43.4% and 15.4% of Africans had extraocular retinoblastoma and distant metastasis at the time of diagnosis, respectively, compared to 2.9% and 1.0% of the Europeans. To reach a retinoblastoma centre, European patients travelled 421.8 km compared to Africans who travelled 185.7 km (p&lt;0.001). On regression analysis, lower-national income level, African residence and older age (p&lt;0.001), but not travel distance (p=0.19), were risk factors for advanced disease. Conclusions Fewer than half the expected number of patients with retinoblastoma presented to African referral centres in 2017, suggesting poor awareness or other barriers to access. Despite the relatively shorter distance travelled by African patients, they presented with later-stage disease. Health education about retinoblastoma is needed for carers and health workers in Africa in order to increase capture rate and promote early referral.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30207 - Ophthalmology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

British Journal of Ophthalmology

ISSN

0007-1161

e-ISSN

—

Svazek periodika

105

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

1435-1443

Kód UT WoS článku

000702446300022

EID výsledku v databázi Scopus

2-s2.0-85091841297