Regulation of neuronal bioenergetics as a therapeutic strategy in neurodegenerative diseases
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00075087" target="_blank" >RIV/00159816:_____/21:00075087 - isvavai.cz</a>
Výsledek na webu
<a href="https://www.nrronline.org/temp/NeuralRegenRes1681467-5402109_150021.pdf" target="_blank" >https://www.nrronline.org/temp/NeuralRegenRes1681467-5402109_150021.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4103/1673-5374.303007" target="_blank" >10.4103/1673-5374.303007</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Regulation of neuronal bioenergetics as a therapeutic strategy in neurodegenerative diseases
Popis výsledku v původním jazyce
Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis are a heterogeneous group of debilitating disorders with multifactorial etiologies and pathogeneses that manifest distinct molecular mechanisms and clinical manifestations with abnormal protein dynamics and impaired bioenergetics. Mitochondrial dysfunction is emerging as an important feature in the etiopathogenesis of these age-related neurodegenerative diseases. The prevalence and incidence of these diseases is on the rise with the increasing global population and average lifespan. Although many therapeutic approaches have been tested, there are currently no effective treatment routes for the prevention or cure of these diseases. We present the current status of our knowledge and understanding of the involvement of mitochondrial dysfunction in these diseases and highlight recent advances in novel therapeutic strategies targeting neuronal bioenergetics as potential approach for treating these diseases.
Název v anglickém jazyce
Regulation of neuronal bioenergetics as a therapeutic strategy in neurodegenerative diseases
Popis výsledku anglicky
Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis are a heterogeneous group of debilitating disorders with multifactorial etiologies and pathogeneses that manifest distinct molecular mechanisms and clinical manifestations with abnormal protein dynamics and impaired bioenergetics. Mitochondrial dysfunction is emerging as an important feature in the etiopathogenesis of these age-related neurodegenerative diseases. The prevalence and incidence of these diseases is on the rise with the increasing global population and average lifespan. Although many therapeutic approaches have been tested, there are currently no effective treatment routes for the prevention or cure of these diseases. We present the current status of our knowledge and understanding of the involvement of mitochondrial dysfunction in these diseases and highlight recent advances in novel therapeutic strategies targeting neuronal bioenergetics as potential approach for treating these diseases.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10601 - Cell biology
Návaznosti výsledku
Projekt
<a href="/cs/project/EF15_003%2F0000492" target="_blank" >EF15_003/0000492: Mapování molekulární podstaty procesů stárnutí pro vývoj nových léčebných metod</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2021
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Neural Regeneration Research
ISSN
1673-5374
e-ISSN
—
Svazek periodika
16
Číslo periodika v rámci svazku
8
Stát vydavatele periodika
IN - Indická republika
Počet stran výsledku
16
Strana od-do
1467-1482
Kód UT WoS článku
000609622400003
EID výsledku v databázi Scopus
—